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005			20250625162440.0
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090			_aB-19986
245	1	0	_aRole of wound microbiome, strategies of microbiota delivery system and clinical management
490	0		_vAdvanced Drug Delivery Reviews, 192, p.114671, 2023
520	3		_aDelayed wound healing is one of the most global public health threats affecting nearly 100 million people each year, particularly the chronic wounds. Many confounding factors such as aging, diabetic disease, medication, peripheral neuropathy, immunocompromises or arterial and venous insufficiency hyperglycaemia are considered to inhibit wound healing. Therapeutic approaches for slow wound healing include anti-infection, debridement and the use of various wound dressings. However, the current clinical outcomes are still unsatisfied. In this review, we discuss the role of skin and wound commensal microbiota in the different healing stages, including inflammation, cell proliferation, re-epithelialization and remodelling phase, followed by multiple immune cell responses to commensal microbiota. Current clinical management in treating surgical wounds and chronic wounds was also reviewed together with potential controlled delivery systems which may be utilized in the future for the topical administration of probiotics and microbiomes. This review aims to introduce advances, novel strategies, and pioneer ideas in regulating the wound microbiome and the design of controlled delivery systems.
650	1	4	_aCELL RESPONSE TO MICROBIOME
650	1	4	_aCLINICAL WOUND CARE
650	1	4	_aINFLAMMATION
650	1	4	_aPROBIOTIC DELIVERY
650	1	4	_aSKIN MICROBIOME
650	1	4	_aWOUND HEALING
700	1	2	_aTang, Q.
700	1	2	_aXue, N.
700	1	2	_aDing, X.
700	1	2	_aTsai, K. H. Y.
700	1	2	_aHew, J. J.
700	1	2	_aJiang, R.
700	1	2	_aWang, Y.
856	4	0	_uhttps://drive.google.com/file/d/11aHwZ4Zukz_Y56gDrolr7GTKvMzOLmna/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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