000			02999nam a2200301Ia 4500
003			MX-MdCICY
005			20250625162441.0
040			_cCICY
090			_aB-20036
245	1	0	_aAdvances in the activity evaluation and cellular regulation pathways of food-derived antioxidant peptides
490	0		_vTrends in Food Science & Technology, 122, p.171-186, 2022
520	3		_aBackground: Oxidative stress is the main reason for inducing cell apoptosis, tissue damage and pathological changes in the body. Antioxidants can be taken to eliminate radicals and reduce the incidence of hypertension, cardiovascular disease, and hypertension. Food-derived antioxidant peptides are prepared by enzymatic hydrolysis of edible protein. Because of its small molecular weight, high antioxidant activity, and strong safety characteristics, it has gradually become a safe and effective antioxidant. Scope and approach: This article provides a detailed and up-to-date review of food-derived antioxidant peptides from their preparation, activity evaluation, transport and absorption, mechanism of action, and antioxidant-mediated functional activities. In addition, this review emphasizes multiple targeted regulatory pathways of antioxidant peptides to clarify how they exert their mediated functional activity. Key findings: Antioxidant peptides from different sources may have different biological activities and targeting functions due to their natural ingredients and preparation methods. The properties of the polypeptide can be improved by adjusting the parameters of enzymatic hydrolysis. In addition, PEF and Maillard reaction treatment can also enhance the activity of food-derived peptides. The antioxidant mechanism of food-derived peptides can be divided into three types, regulating the production of ROS, regulating enzyme activity, and regulating the antioxidant pathway. Our review especially describes the regulation and molecular mechanisms of Keap1-Nrf2- ARE, NF-?B, MAPK and PI3K/AKT/mTOR pathways. Finally, peptides may act on multiple pathways simultaneously to exert their antioxidant-mediated functional activities. Nowadays, food-derived antioxidant peptides have become a new research direction in functional foods, and have broad prospects. However, how to use food-derived antioxidant peptides that gradually replace synthetic antioxidants requires further research.
650	1	4	_aANTIOXIDANT PEPTIDE
650	1	4	_aPREPARATION
650	1	4	_aACTIVITY IMPROVEMENT
650	1	4	_aTRANSPORT AND ABSORPTION
650	1	4	_aREGULATION MECHANISM
650	1	4	_aANTIOXIDANT-MEDIATED FUNCTIONAL ACTIVITIES
700	1	2	_aLv, R.
700	1	2	_aDong, Y.
700	1	2	_aBao, Z.
700	1	2	_aZhang, S.
700	1	2	_aLin, S.
700	1	2	_aSun, N.
856	4	0	_uhttps://drive.google.com/file/d/1RDtkddiv41Hf9139gTum1Y7zJEKpIEH1/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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