000 02275nam a2200265Ia 4500
003 MX-MdCICY
005 20250625162448.0
040 _cCICY
090 _aB-20411
245 1 0 _aMechanism unravelling the effect of 1-Methylcyclopropene (1-MCP)through molecular docking approach and postharvest analysis in papaya
490 0 _vPlant Physiology Reports, 28(3), p.448-458, 2023
520 3 _a1-Methylcyclopropene (1-MCP), an ethylene receptor inhibitor, has been widely applied in delaying the ripening of fruits including several tropical and temperate fruit crops. A molecular docking approach has been attempted in this study to understand the effect of 1-MCP and ethylene in regulating the fruit ripening process in addition to postharvest wet lab experiments. The molecular docking approach executed in this study is a first of kind approach to study the interaction of 1-MCP and ethylene molecule to the ethylene binding receptor protein and study the effectiveness of 1-MCP in inhibiting ethylene responses. Also, using bioinformatics tools, an attempt was made to predict the complete protein structure of ethylene receptors ETR1 and ERS1, which is not available so far. The in-silico approach and postharvest studies reveal that 1-MCP has higher affinity to bind ethylene receptors (less binding energy)than ethylene, confirming its efficacy on inhibiting ethylene signaling, thus can also be regarded as ethylene perception inhibitor. Hence, 1-MCP has a greater scope in delaying the ripening process as observed in the present investigation. The study also shows a plausible mechanism at the molecular level for delaying ripening process in papaya fruit which paves way to identify alternative GRAS compounds to extend shelf life of perishables.
650 1 4 _aFRUIT RIPENING
650 1 4 _aPOSTHARVEST
650 1 4 _aETHYLENE RECEPTOR
650 1 4 _aSHELF LIFE
650 1 4 _aMOLECULAR DOCKING
650 1 4 _aLIGAND INTERACTION
700 1 2 _aSrividhya, S.
700 1 2 _aJayakanthan, M.
700 1 2 _aJeyakumar, P.
856 4 0 _uhttps://drive.google.com/file/d/1WjS_QO38zk10DcBVLh8MAssfIo6v7o5t/view?usp=drivesdk
_zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942 _2Loc
_cREF1
008 250602s9999 xx |||||s2 |||| ||und|d
999 _c54506
_d54506