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245	1	0	_aIn vitro antifungal activity of extract and plumbagin from the stem bark of Diospyros crassiflora Hiern (Ebenaceae)
490	0		_vPhytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, 21(7), p.671-674, 2007
520	3		_aIn this study the methanol/dichloromethane (1:1)extract and plumbagin isolated from extract of stem barks of Diospyros crassiflora were tested for their antifungal activity against 12 strains of yeast pathogens and filamentous fungi: Candida albicans, Candida glabrata, Candida krusei, Candida tropicalis, Cryptococcus neoformans, Aspergillus niger, Aspergillus flavus, Alternaria sp., Cladosporium sp., Geotrichum candidum, Fusarium sp. and Penicillium sp. The growth of all fungi strains tested was inhibited by the extract and plumbagin. The diameter of inhibition zones varied from 12 to 18 mm and from 21 to 35 mm for the extract and plumbagin, respectively. The MIC values ranged from 12.5 to 25 mg/mL for the extract and 0.78-3.12 microg/mL for plumbagin. It is therefore suggested that extracts from the stem bark of Diospyros crassiflora could be used traditionally in the treatment of fungal infections. Compared with ketoconazole used as a standard antifungal, plumbagin could be considered as a promising antifungal agent.
650	1	4	_aDIOSPYROS CRASSIFLORA
650	1	4	_aEBENACEAE
650	1	4	_aPLUMBAGIN
650	1	4	_aANTIFUNGAL ACTIVITY
700	1	2	_aDzoyem, J. P.
700	1	2	_aTangmouo, J. G.
700	1	2	_aLontsi, D.
700	1	2	_aEtoa, F. X.
700	1	2	_aLohoue, P. J.
856	4	0	_uhttps://drive.google.com/file/d/1BM2LylQjCoWmkZ623wwu-Z0pMbkW03eG/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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