000			01832nam a2200301Ia 4500
003			MX-MdCICY
005			20250625162449.0
040			_cCICY
090			_aB-20453
245	1	0	_aInduction of ambuic acid derivatives by the endophytic fungus Pestalotiopsis lespedezae through an OSMAC approach
490	0		_vTetrahedron, 79, p.131876, 2021
520	3		_aTen new ambuic acid derivatives, pestallic acids H-Q including one new iodinated natural product along with two known compounds, ambuic acid and ambuic acid 18-acetate, were obtained through fermentation of the endophytic fungus Pestalotiopsis lespedezae on solid rice medium with 3.5 percent NaI. Pestallic acids H-Q were undetectable in cultures of the fungus grown on solid rice medium lacking NaI or in those where NaI had been replaced by NaCl or NaBr. The structures of the new metabolites were established on basis of 1D/2D NMR and HRESIMS data. Their absolute configurations were determined by Mosher's method and TDDFT-ECD calculations. The compounds failed to show antibacterial activity against S. aureus (ATCC29213), drug-resistant Acinetobacter baumannii (BAA1605)or Mycobacterium tuberculosis, as well as cytotoxicity against the mouse lymphoma cell line L5178Y.
650	1	4	_aENDOPHYTIC FUNGUS
650	1	4	_aPESTALOTIOPSIS LESPEDEZAE
650	1	4	_aPESTALLIC ACIDS
650	1	4	_aIODINATED NATURAL PRODUCT
650	1	4	_aTDDFT-ECD
700	1	2	_aYu, X.
700	1	2	_aGao, Y.
700	1	2	_aFrank, M.
700	1	2	_aMándi, A.
700	1	2	_aKurtán, T.
700	1	2	_aMüller, W. E.
700	1	2	_aProksch, P.
856	4	0	_uhttps://drive.google.com/file/d/1kIItIE2qmE5NNzn6gr-kzYXkm-sH8_U7/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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