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003			MX-MdCICY
005			20250625162451.0
040			_cCICY
090			_aB-20593
245	1	0	_aChitosan-based scaffolds as drug delivery systems in bone tissue engineering.
490	0		_vInternational Journal of Biological Macromolecules, 222(Pt A), p.132-153, 2022
520	3		_aThe bone tissue engineering approach for treating large bone defects becomes necessary when the tissue damage surpasses the threshold of the inherent regenerative ability of the human body. A myriad of natural biodegradable polymers and scaffold fabrication techniques have emerged in the last decade. Chitosan (CS)is especially attractive as a bone scaffold material to support cell attachment and proliferation and mineralization of the bone matrix. The primary amino groups in CS are responsible for properties such as controlled drug release, mucoadhesion, in situ gelation, and transfection. CS-based smart drug delivery scaffolds that respond to environmental stimuli have been reported to have a localized sustained delivery of drugs in the large bone defect area. This review outlines the recent advances in the fabrication of CS-based scaffolds as a pharmaceutical carrier to deliver drugs such as antibiotics, growth factors, nucleic acids, and phenolic compounds for bone tissue regeneration.
650	1	4	_aBONE TISSUE ENGINEERING
650	1	4	_aCHITOSAN
650	1	4	_aDRUG DELIVERY
650	1	4	_aOSTEOMIMETIC
650	1	4	_aSCAFFOLDS
700	1	2	_aBharathi, R.
700	1	2	_aGanesh, S. S.
700	1	2	_aHarini, G.
700	1	2	_aVatsala, K.
700	1	2	_aAnushikaa, R.
700	1	2	_aAravind, S.
700	1	2	_aSelvamurugan, N.
856	4	0	_uhttps://drive.google.com/file/d/1FmJm9tzWQSVvoC-jeUcmM6vIu3bwJSTD/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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