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245	1	0	_aNLR functions in plant and animal immune systems: so far and yet so close
490	0		_vNature immunology, 12(9), p.817-826, 2011
520	3		_aIn plants and animals, the NLR family of receptors perceives non-self and modified-self molecules inside host cells and mediates innate immune responses to microbial pathogens. Despite their similar biological functions and protein architecture, animal NLRs are normally activated by conserved microbe- or damage-associated molecular patterns, whereas plant NLRs typically detect strain-specific pathogen effectors. Plant NLRs recognize either the effector structure or effector-mediated modifications of host proteins. The latter indirect mechanism for the perception of non-self, as well as the within-species diversification of plant NLRs, maximize the capacity to recognize non-self through the use of a finite number of innate immunoreceptors. We discuss recent insights into NLR activation, signal initiation through the homotypic association of N-terminal domains and subcellular receptor dynamics in plants and compare those with NLR functions in animals.
700	1	2	_aMaekawa, T.
700	1	2	_aKufer, T. A.
700	1	2	_aSchulze-Lefert, P.
856	4	0	_uhttps://drive.google.com/file/d/1ZDDHX97aO7QjA_L4Z54wSReMraFYX5cf/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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