| 000 | 02262nam a2200337Ia 4500 | ||
|---|---|---|---|
| 003 | MX-MdCICY | ||
| 005 | 20250625162452.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-20641 | ||
| 245 | 1 | 0 | _aThymbra capitata essential oil has a significant antimicrobial activity against methicillin-resistant Staphylococcus aureus pre-formed biofilms |
| 490 | 0 | _vLetters in Applied MicroBiology, 74(5), p.787-795, 2022 | |
| 520 | 3 | _aMethicillin-resistant Staphylococcus aureus (MRSA)is a multidrug-resistant opportunistic pathogen with a great ability to form biofilms. Herein, the antimicrobial potential of Thymbra capitata essential oil (EO)against MRSA biofilms was investigated. The determination of the minimum inhibitory concentration (MIC)and the minimum lethal concentration (MLC)of the T. capitata EO was first investigated on a group of clinical isolates from septicaemias, diabetic foot ulcers and osteomyelitis. Biofilms were incubated with the EO at the MLC and its anti-biofilm potential was investigated. A strong antimicrobial activity was observed, with MIC and MLC values between 0·32 and 0·64 mg l-1 . However, the concentration of EO necessary for the eradication of planktonic cells was insufficient to significantly reduce the biofilm biomass of some isolates. Nevertheless, cell culturability and overall cellular metabolism was strongly reduced in all biofilms tested, only when the EO was tested. Contrary to the tested antibiotics, T. capitata EO showed a significant antimicrobial activity against MRSA biofilms, by reducing cellular metabolism and cellular culturability. | |
| 650 | 1 | 4 | _aEO |
| 650 | 1 | 4 | _aMRSA |
| 650 | 1 | 4 | _aXTT |
| 650 | 1 | 4 | _aBIOFILM BIOMASS |
| 650 | 1 | 4 | _aCELL CULTURABILITY |
| 650 | 1 | 4 | _aCELLULAR ACTIVITY |
| 650 | 1 | 4 | _aMINIMUM INHIBITORY CONCENTRATION |
| 650 | 1 | 4 | _aMINIMUM LETHAL CONCENTRATION |
| 700 | 1 | 2 | _aAlmeida, L. |
| 700 | 1 | 2 | _aLopes, N. |
| 700 | 1 | 2 | _aGaio, V. |
| 700 | 1 | 2 | _aCavaleiro, C. |
| 700 | 1 | 2 | _aSalgueiro, L. |
| 700 | 1 | 2 | _aSilva, V. |
| 700 | 1 | 2 | _aCerca, N. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/18OnYT1IcP5GjENV8oQhxSENt214JkyeZ/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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