| 000 | 01718nam a2200277Ia 4500 | ||
|---|---|---|---|
| 003 | MX-MdCICY | ||
| 005 | 20250625162453.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-20677 | ||
| 245 | 1 | 0 | _aToehold Switches; a foothold for Synthetic Biology |
| 490 | 0 | _vBiotechnology and BioEngineering, 120(4), p.932-952, 2023 | |
| 520 | 3 | _aToehold switches are de novo designed riboregulators that contain two RNA components interacting through linear-linear RNA interactions, regulating the gene expression. These are highly versatile, exhibit excellent orthogonality, wide dynamic range, and are highly programmable, so can be used for various applications in synthetic biology. In this review, we summarized and discussed the design characteristics and benefits of toehold switch riboregulators over conventional riboregulators. We also discussed applications and recent advancements of toehold switch riboregulators in various fields like gene editing, DNA nanotechnology, translational repression, and diagnostics (detection of microRNAs and some pathogens). Toehold switches, therefore, furnished advancement in synthetic biology applications in various fields with their prominent features. | |
| 650 | 1 | 4 | _aDNA NANOTECHNOLOGY |
| 650 | 1 | 4 | _aGENE EDITING |
| 650 | 1 | 4 | _aGENE EXPRESSION |
| 650 | 1 | 4 | _aORTHOGONALITY |
| 650 | 1 | 4 | _aRIBOREGULATORS |
| 650 | 1 | 4 | _aSYNTHETIC BIOLOGY |
| 650 | 1 | 4 | _aTOEHOLD SWITCHES |
| 700 | 1 | 2 | _aYarra, S. S. |
| 700 | 1 | 2 | _aAshok, G. |
| 700 | 1 | 2 | _aMohan, U. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/14TCkGZmUm1n8wPWi7PUqgXkNvwb8RY3n/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 |
_2Loc _cREF1 |
||
| 008 | 250602s9999 xx |||||s2 |||| ||und|d | ||
| 999 |
_c54763 _d54763 |
||