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090			_aB-20744
245	1	0	_aPolysaccharide-bioceramic composites for bone tissue engineering: A review
490	0		_vInternational Journal of Biological Macromolecules, 250, p.126237, 2023
520	3		_aLimitations associated with conventional bone substitutes such as autografts, increasing demand for bone grafts, and growing elderly population worldwide necessitate development of unique materials as bone graft substitutes. Bone tissue engineering (BTE)would ensure therapy advancement, efficiency, and cost-effective treatment modalities of bone defects. One way of engineering bone tissue scaffolds by mimicking natural bone tissue composed of organic and inorganic phases is to utilize polysaccharide-bioceramic hybrid composites. Polysaccharides are abundant in nature, and present in human body. Biominerals, like hydroxyapatite are present in natural bone and some of them possess osteoconductive and osteoinductive properties. Ion doped bioceramics could substitute protein-based biosignal molecules to achieve osteogenesis, vasculogenesis, angiogenesis, and stress shielding. This review is a systemic summary on properties, advantages, and limitations of polysaccharide-bioceramic/ion doped bioceramic composites along with their recent advancements in BTE.
650	1	4	_aBONE SUBSTITUTES
650	1	4	_aBIOACTIVITY
650	1	4	_aCALCIUM PHOSPHATE
650	1	4	_aBIOGLASS
650	1	4	_aCALCIUM SILICATE
700	1	2	_aSivakumar, P. M.
700	1	2	_aYetisgin, A. A.
700	1	2	_aDemir, E.
700	1	2	_aSahin, S. B.
700	1	2	_aCetinel, S.
856	4	0	_uhttps://drive.google.com/file/d/18SUf983vs8so1bWlZEOZyupPPP0tPbm2/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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