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245	1	0	_aGeranylgeraniol is a potent inducer of apoptosis in tumor cells
490	0		_vThe Journal of BioChemistry, 117(1), p.11-13, 1995
520	3		_aWe screened various isoprenoids to find inducers of apoptosis for human leukemia HL-60 cells, and found that GGO (geranylgeraniol)had the most potent apoptosis-inducing activity, as judged from DNA fragmentation in HL-60 cells. The apoptosis-inducing activity of GGO is concentration- and time-dependent. DNA synthesis by HL-60 cells was selectively inhibited on treatment with GGO. Besides HL-60 cells, apoptosis was induced by GGO in various tumor cell lines, including human myeloid multipotential leukemia K562, lymphoblastic leukemia Molt3, and colon adenocarcinoma COLO320 DM.
650	1	4	_aAPOPTOSIS
650	1	4	_aGERANYLGERANIOL
650	1	4	_aISOPRENOID
650	1	4	_aTUMOR CELL
700	1	2	_aOhizumi, H.
700	1	2	_aMasuda, Y.
700	1	2	_aNakajo, S.
700	1	2	_aSakai, I.
700	1	2	_aOhsawa, S.
700	1	2	_aNakaya, K.
856	4	0	_uhttps://drive.google.com/file/d/1rU3s55qtDLZw_f82xYrSIGH2pxFOOLAW/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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