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245 1 0 _aA new NLR gene for resistance to tomato spotted wilt virus in tomato (Solanum lycopersicum)
490 0 _vTheoretical and Applied Genetics, 135(5), p.1493-1509, 2022
520 3 _aA typical NLR gene, Sl5R-1, which regulates Tomato spotted wilt virus resistance, was fine mapped to a region less than 145 kb in the tomato genome. Tomato spotted wilt is a viral disease caused by Tomato spotted wilt virus (TSWV), which is a devastating disease that affects tomato (Solanum lycopersicum)production worldwide, and the resistance provided by the Sw-5 gene has broken down in some cases. In order to identify additional genes that confer resistance to TSWV, the F2 population was mapped using susceptible (M82)and resistant (H149)tomato lines. After 3 years of mapping, the main quantitative trait locus on chromosome 05 was narrowed to a genomic region of 145 kb and was subsequently identified by the F2 population, with 1971 plants in 2020. This region encompassed 14 candidate genes, and in it was found a gene cluster consisting of three genes (Sl5R-1, Sl5R-2, and Sl5R-3)that code for NBS-LRR proteins. The qRT-PCR and virus-induced gene silencing approach results confirmed that Sl5R-1 is a functional resistance gene for TSWV. Analysis of the Sl5R-1 promoter region revealed that there is a SlTGA9 transcription factor binding site caused by a base deletion in resistant plants, and its expression level was significantly up-regulated in infected resistant plants. Analysis of salicylic acid (SA)and jasmonic acid (JA)levels and the expression of SA- and JA-regulated genes suggest that SlTGA9 interacts or positively regulates Sl5R-1 to affect the SA- and JA-signaling pathways to resist TSWV. These results demonstrate that the identified Sl5R-1 gene regulates TSWV resistance by its own promoter interacting with the transcription factor SlTGA9.
700 1 2 _aQi, S.
700 1 2 _aShen, Y.
700 1 2 _aWang, X.
700 1 2 _aZhang, S.
700 1 2 _aLi, Y.
700 1 2 _aIslam, M. M.
700 1 2 _aLiang, Y.
856 4 0 _uhttps://drive.google.com/file/d/1j8bAEBPdfLHyhP4bu1f3i6E_d6Hs3i8p/view?usp=drivesdk
_zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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