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090			_aB-20916
245	1	0	_aRapid single-particle chemical imaging of nanoplastics by SRS microscopy
490	0		_vProceedings of the National Academy of Sciences, 121(3), p. e2300582121, 2024
520	3		_aPlastics are now omnipresent in our daily lives. The existence of microplastics (1 µm to 5 mm in length)and possibly even nanoplastics (<1 ?m)has recently raised health concerns. In particular, nanoplastics are believed to be more toxic since their smaller size renders them much more amenable, compared to microplastics, to enter the human body. However, detecting nanoplastics imposes tremendous analytical challenges on both the nano-level sensitivity and the plastic-identifying specificity, leading to a knowledge gap in this mysterious nanoworld surrounding us. To address these challenges, we developed a hyperspectral stimulated Raman scattering (SRS)imaging platform with an automated plastic identification algorithm that allows micro-nano plastic analysis at the single-particle level with high chemical specificity and throughput. We first validated the sensitivity enhancement of the narrow band of SRS to enable high-speed single nanoplastic detection below 100 nm. We then devised a data-driven spectral matching algorithm to address spectral identification challenges imposed by sensitive narrow-band hyperspectral imaging and achieve robust determination of common plastic polymers. With the established technique, we studied the micro-nano plastics from bottled water as a model system. We successfully detected and identified nanoplastics from major plastic types. Micro-nano plastics concentrations were estimated to be about 2.4 ± 1.3 × 105 particles per liter of bottled water, about 90 percent of which are nanoplastics. This is orders of magnitude more than the microplastic abundance reported previously in bottled water. High-throughput single-particle counting revealed extraordinary particle heterogeneity and nonorthogonality between plastic composition and morphologies; the resulting multidimensional profiling sheds light on the science of nanoplastics.
650	1	4	_aRAMAN IMAGING
650	1	4	_aSTIMULATED RAMAN SCATTERING
650	1	4	_aNANOPLASTICS
650	1	4	_aOPTICAL MICROSCOPY
650	1	4	_aSINGLE PARTICLE ANALYSIS
700	1	2	_aQian, N.
700	1	2	_aGao, X.
700	1	2	_aLang, X.
700	1	2	_aDeng, H.
700	1	2	_aBratu, T. M.
700	1	2	_aChen, Q.
700	1	2	_aMin, W.
856	4	0	_uhttps://drive.google.com/file/d/1rJJ0dta7GOF7sTrkoPs5tDmsVMQ3k9ao/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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