| 000 | 02477nam a2200277Ia 4500 | ||
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| 003 | MX-MdCICY | ||
| 005 | 20250625162459.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-20982 | ||
| 245 | 1 | 0 | _aCornstarch aerogels with thymol, citronellol, carvacrol, and eugenol prepared by supercritical CO2-assisted techniques for potential biomedical applications |
| 490 | 0 | _vCarbohydrate Polymers, 331, p.121874, 2024 | |
| 520 | 3 | _aThis study focuses on the development of bioactive materials using environmentally friendly techniques, renewable, biocompatible, and biodegradable polysaccharide, as well as natural bioactive compounds (NBCs)found in plant extracts. First, cornstarch aerogels with a porosity of 86 percent and a specific surface area of 225 m2/g were produced via supercritical CO2- assisted drying. Further, thymol, citronellol, carvacrol, and eugenol were incorporated into the aerogels by supercritical CO2- assisted impregnation, which allowed variation in loadings of NBCs (12.8-17.6 percent). Interaction between cornstarch aerogels and NBCs determined impregnation rate, pore wall thickness (in the range 18-95 nm), liquid absorption capacity (from 265 to 569 percent), dehydration mass loss, and release in phosphate-buffered saline. Controlled release of NBCs was maintained over a 3-day period. Moreover, impregnated aerogels showed a significant antioxidant effect with the highest value for DPPH radical inhibition of 25.5 percent determined for the aerogels impregnated with eugenol. Notable antimicrobial activity against tested Gram-negative bacteria, Gram-positive bacteria, and fungi was also observed, being the highest for thymol-loaded aerogel with the diameter of the inhibition zones of up to 37.5 mm. This work shows a promising green approach for the production of bioactive two-component starch-based materials for potential applications in skin infection treatment. | |
| 650 | 1 | 4 | _aPOLYSACCHARIDE BIOMATERIAL |
| 650 | 1 | 4 | _aSTARCH AEROGEL |
| 650 | 1 | 4 | _aSUPERCRITICAL DRYING |
| 650 | 1 | 4 | _aCONTROLLED RELÉASE |
| 650 | 1 | 4 | _aNATURAL BIOACTIVE COMPOUNDS |
| 650 | 1 | 4 | _aANTIMICROBIAL ACTIVITY |
| 700 | 1 | 2 | _aMilovanovic, S. |
| 700 | 1 | 2 | _aMarkovic, D. |
| 700 | 1 | 2 | _aJankovic-Castvan, I. |
| 700 | 1 | 2 | _aLukic, I. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1fr0uVO89NQGagB3RgcfDWPuFwkuvz72B/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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