000			02029nam a2200241Ia 4500
003			MX-MdCICY
005			20250625162459.0
040			_cCICY
090			_aB-21006
245	1	0	_aAntiviral profiling of C-18-or C-19-functionalized semisynthetic Abietane diterpenoids
490	0		_vJournal of Natural Products, 85(8), p.2044-2051, 2022
520	3		_aViral infections affect several million patients annually.Although hundreds of viruses are known to be pathogenic, only a few can be treated in the clinic with available antiviral drugs. Naturally based pharmacotherapy may be a proper alternative for treating viral diseases.Several natural and semisynthetic abietane-type diterpenoids have shown important antiviral activities. In this study, a biological evaluation of a number of either C-18- or C-19-functionalized known semisynthetic abietanes against Zika virus, Dengue virus, Herpes virus simplex type 1, and Chikungunya virus are reported. Semisynthetic abietane ferruginol and its analogue 18-(phthalimid-2-yl)ferruginol displayed broad-spectrum antiviral properties. The scale-up synthesis of this analogue has been optimized for further studies and development. This molecule displayed an EC50 between 5.0 and 10.0 ?M against Colombian Zika virus strains and EC50 = 9.8 ?M against Chikungunya virus. Knowing that this ferruginol analogue is also active against Dengue virus type 2 (EC50 = 1.4 ?M, DENV-2), we can conclude that this compound is a promising broad-spectrum antiviral agent paving the way for the development of novel antivirals.
700	1	2	_aGonzález-Cardenete, M. A.
700	1	2	_aHamulic, D.
700	1	2	_aMiquel-Leal, F. J.
700	1	2	_aGonzález-Zapata, N.
700	1	2	_aJimenez-Jarava, O. J.
700	1	2	_aBrand, Y. M.
700	1	2	_aMarín, M. L.
856	4	0	_uhttps://drive.google.com/open?id=1VW4MY8sWRhORrlyjOGdmzaA_N9M8ooO_&usp=drive_copy _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c55084 _d55084