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090			_aB-21053
245	1	0	_aMicrobial Metabolism of Caffeine and Potential Applications in Bioremediation
490	0		_vJournal of Applied MicroBiology, 135(4), p.lxae080, 2024
520	3		_aWith increasing global consumption of caffeine-rich products, such as coffee, tea, and energy drinks, there is also an increase in urban and processing waste full of residual caffeine with limited disposal options. This waste caffeine has been found to leach into the surrounding environment where it poses a threat to microorganisms, insects, small animals, and entire ecosystems. Growing interest in harnessing this environmental contaminant has led to the discovery of 79 bacterial strains, eight yeast strains, and 32 fungal strains capable of metabolizing caffeine by N-demethylation and/or C-8 oxidation. Recently observed promiscuity of caffeine-degrading enzymes in vivo has opened up the possibility of engineering bacterial strains capable of producing a wide variety of caffeine derivatives from a renewable resource. These engineered strains can be used to reduce the negative environmental impact of leached caffeine-rich waste through bioremediation efforts supplemented by our increasing understanding of new techniques such as cell immobilization. Here, we compile all of the known caffeine-degrading microbial strains, discuss their metabolism and related enzymology, and investigate their potential application in bioremediation.
650	1	4	_aN-DEMETHYLATION
650	1	4	_aPSEUDOMONAS
650	1	4	_aC-8 OXIDATION
650	1	4	_aBIOREMEDIATION
650	1	4	_aCAFFEINE
650	1	4	_aMETHYLXANTHINES
700	1	2	_aMock, M. B.
700	1	2	_aSummers, R. M.
856	4	0	_uhttps://drive.google.com/open?id=1fpJLPPUA_KpvDiHVc0b5Oxq6CsgnMau-&usp=drive_copy _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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