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003			MX-MdCICY
005			20250625162501.0
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090			_aB-21114
245	1	0	_aAdenylate cyclase activity of TIR1/AFB auxin receptors in plants
490	0		_vNature, 611(7934), p.133-138, 2022
520	3		_aThe phytohormone auxin is the major coordinative signal in plant development1, mediating transcriptional reprogramming by a well-established canonical signalling pathway. TRANSPORT INHIBITOR RESPONSE 1 (TIR1)/AUXIN-SIGNALING F-BOX (AFB)auxin receptors are F-box subunits of ubiquitin ligase complexes. In response to auxin, they associate with Aux/IAA transcriptional repressors and target them for degradation via ubiquitination2,3. Here we identify adenylate cyclase (AC)activity as an additional function of TIR1/AFB receptors across land plants. Auxin, together with Aux/IAAs, stimulates cAMP production. Three separate mutations in the AC motif of the TIR1 C-terminal region, all of which abolish the AC activity, each render TIR1 ineffective in mediating gravitropism and sustained auxin-induced root growth inhibition, and also affect auxin-induced transcriptional regulation. These results highlight the importance of TIR1/AFB AC activity in canonical auxin signalling. They also identify a unique phytohormone receptor cassette combining F-box and AC motifs, and the role of cAMP as a second messenger in plants.
700	1	2	_aQi, L.
700	1	2	_aKwiatkowski, M.
700	1	2	_aChen, H.
700	1	2	_aHoermayer, L.
700	1	2	_aSinclair, S.
700	1	2	_aZou, M.
700	1	2	_aFriml, J.
856	4	0	_uhttps://drive.google.com/open?id=12rgOxxeV8pjHv6iVBgfTN7BFaKgK2I5F&usp=drive_copy _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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