| 000 | 02382nam a2200241Ia 4500 | ||
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| 003 | MX-MdCICY | ||
| 005 | 20250625164352.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-21281 | ||
| 245 | 1 | 0 | _aGelatin microsphere-alginate hydrogel combined system for sustained and gastric targeted delivery of 5-fluorouracil |
| 490 | 0 | _aInternational Journal of Biological Macromolecules. 255, 128022, 2024, DOI: 10.1016/j.ijbiomac.2023.128022 | |
| 520 | 3 | _aIn the current study, novel gelatin microspheres/methacrylated alginate hydrogel combined system (5-FU-GELms/Alg-MA) was developed for gastric targeted delivery of 5-fluorouracil as an anticancer agent. While water-in-oil emulsification method was used for the production of 5-FU-GELms, Alg-MA was synthesized through methacrylation reaction occurred by epoxide ring-opening mechanism. Then, 5-FU-GELms/Alg-MA hydrogel system was fabricated by the encapsulation of 5-FU-GELms into Alg-MA hydrogel network via UV-crosslinking. To evaluate applicability of fabricated 5-FU-GELms/Alg-MA as gastric targeted drug delivery vehicle, both swelling and in vitro drug release experiments were carried out at pH 1.2 medium resembling gastric fluid. Compared to drug release directly from 5-FU-GELms, 5-FU-GELms/Alg-MA hydrogel system showed more controlled and sustained drug release profile with lower amount of cumulative release starting from early stages, since hydrogel matrix created a barrier to the diffusion of 5-FU included in microspheres. Drug release kinetic results obtained by applying various kinetic models to release data showed that the mechanism of 5-FU release from 5-FU-GELms/Alg-MA hydrogel system is controlled by Fickian diffusion. All results revealed that 5-FU-GELms/Alg-MA hydrogel integrated system could be potentially utilized as gastric targeted drug carrier to enhance therapeutic efficacy and reduce systemic side effects in gastric cancer treatments for future studies. © 2023 Elsevier B.V. | |
| 650 | 1 | 4 | _aALGINATE |
| 650 | 1 | 4 | _aGELATIN |
| 650 | 1 | 4 | _aMICROSPHERE-HYDROGEL SYSTEM |
| 700 | 1 | 2 | _aAycan D. |
| 700 | 1 | 2 | _aGül ?. |
| 700 | 1 | 2 | _aYorulmaz V. |
| 700 | 1 | 2 | _aAlemdar N. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1i9ZaGqZypuvA6Uqf6SQWvTRQ2qU-cvA4/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta @cicy.edu.mx |
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