000			01676nam a2200217Ia 4500
003			MX-MdCICY
005			20250625164352.0
040			_cCICY
090			_aB-21301
245	1	0	_aBuilding Synthetic Yeast Factories to Produce Fat-soluble Antioxidants
490	0		_aCurrent Opinion in Biotechnology. 87, 103129, 2024, DOI: 10.1016/j.copbio.2024.103129
520	3		_aFat-soluble antioxidants play a vital role in protecting the body against oxidative stress and damage. The rapid advancements in metabolic engineering and synthetic biology have offered a promising avenue for economically producing fat-soluble antioxidants by engineering microbial chassis. This review provides an overview of the recent progress in engineering yeast microbial factories to produce three main groups of lipophilic antioxidants: carotenoids, vitamin E, and stilbenoids. In addition to discussing the classic strategies employed to improve precursor availability and alleviate carbon flux competition, this review delves deeper into the innovative approaches focusing on enzyme engineering, product sequestration, subcellular compartmentalization, multistage fermentation, and morphology engineering. We conclude the review by highlighting the prospects of microbial engineering for lipophilic antioxidant production. © 2024 Elsevier Ltd
700	1	2	_aZhao Y.
700	1	2	_aYao Z.
700	1	2	_aDesai V.
700	1	2	_aChen D.
700	1	2	_aShao Z.
856	4	0	_uhttps://drive.google.com/file/d/1rpp40v4_o-Lecioi1-etxeIoafwC9lS4/view?usp=drivesdk _zPara ver el documento ingresa a Google con tu cuenta @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c55368 _d55368