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090			_aB-3355
245	1	0	_aCitrate-Based Tannin-Bridged Bone Composites for Lumbar Fusion
490	0		_aAdvanced Functional Materials, 30(27), p.2002438, 2020
500			_aArtículo
520	3		_aConventional bone composites consistently fail to mimic the chemical composition and integrated organic/inorganic structure of natural bone, lacking sufficient mechanics as well as inherent osteoconductivity and osteoinductivity. Through a facile surface coating process, the strong adhesive, tannic acid (TA), is adhered to the surface of the natural bone component, hydroxyapatite (HA), with and without the immobilization of in situ formed silver nanoparticles. Residual functional groups available on the immobilized TA substituents are subsequently covalently linked to the citratebased biodegradable polymer, poly(octamethylene citrate) (POC), effectively bridging the organic and inorganic phases. Due to the synergistic effects of the tannin and citrate components, the obtained citrate-based tannin-bridged bone composites (CTBCs) exhibit vastly improved compression strengths up to 323.0 ± 21.3 MPa compared to 229.9 ± 15.6 MPa for POC-HA, and possess tunable degradation profiles, enhanced biomineralization performance, favorable biocompatibility, increased cell adhesion and proliferation, as well as considerable antimicrobial activity. In vivo study of porous CTBCs using a lumbar fusion model further confirms CTBCs' osteoconductivity and osteoinductivity, promoting bone regeneration. CTBCs possess great potential for bone regeneration applications while the immobilized TA additionally preserves surface bioconjugation sites to further tailor the bioactivity of CTBCs.
650	1	4	_aBIOMIMETICS
650	1	4	_a BONE REGENERATION
650	1	4	_a CITRATE-BASED BIODEGRADABLE POLYMERS
650	1	4	_aCOMPOSITE MATERIALS
650	1	4	_a TANNIN-MEDIATED ADHESION
700	1	2	_aGuo, J.
700	1	2	_aTian, X.
700	1	2	_aXie, D.
700	1	2	_aRahn, K.
700	1	2	_aGerhard, E.
700	1	2	_aKuzma, M. L.
700	1	2	_aYang, J.
856	4	0	_uhttps://drive.google.com/file/d/1FaRsF0XhQVbVjawXbE26OMd-7OMVOubJ/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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