| 000 | 02330nam a2200349Ia 4500 | ||
|---|---|---|---|
| 003 | MX-MdCICY | ||
| 005 | 20250626080925.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-19703 | ||
| 245 | 1 | 0 | _aWAV E3 ubiquitin ligases mediate degradation of IAA32/34 in the TMK1-mediated auxin signaling pathway during apical hook development |
| 490 | 0 | _aProc. Natl. Acad. Sci., 121, p.e2314353121, 2024 | |
| 500 | _aArtÃculo | ||
| 520 | 3 | _aAuxin regulates plant growth and development through downstream signaling pathways, including the best-known SCFTIR1/AFB-Aux/IAA-ARF pathway and several other less characterized "noncanonical" pathways. Recently, one SCFTIR1/AFB-independent noncanonical pathway, mediated by Transmembrane Kinase 1 (TMK1), was discovered through the analyses of its functions in Arabidopsis apical hook development. Asymmetric accumulation of auxin on the concave side of the apical hook triggers DAR1-catalyzed release of the C-terminal of TMK1, which migrates into the nucleus, where it phosphorylates and stabilizes IAA32/34 to inhibit cell elongation, which is essential for full apical hook formation. However, the molecular factors mediating IAA32/34 degradation have not been identified. Here, we show that proteins in the CYTOKININ INDUCED ROOT WAVING 1 (CKRW1)/WAVY GROWTH 3 (WAV3) subfamily act as E3 ubiquitin ligases to target IAA32/34 for ubiquitination and degradation, which is inhibited by TMK1c-mediated phosphorylation. This antagonistic interaction between TMK1c and CKRW1/WAV3 subfamily E3 ubiquitin ligases regulates IAA32/34 levels to control differential cell elongation along opposite sides of the apical hook. | |
| 650 | 1 | 4 | _aWAVY GROWTH 3 |
| 650 | 1 | 4 | _aRING-FINGER E3 UBIQUITIN LIGASE |
| 650 | 1 | 4 | _aAUX/IAA PROTEINS |
| 650 | 1 | 4 | _aTRANSMEMBRANE KINASE 1 |
| 650 | 1 | 4 | _a NONCANONICAL AUXIN SIGNALING |
| 700 | 1 | 2 | _aWang, J.-L. |
| 700 | 1 | 2 | _aWang, M. |
| 700 | 1 | 2 | _aZhang, L. |
| 700 | 1 | 2 | _aLi, Y.-X. |
| 700 | 1 | 2 | _aLi, J.-J. |
| 700 | 1 | 2 | _aLi, Y.-Y. |
| 700 | 1 | 2 | _aPu, Z.-X. |
| 700 | 1 | 2 | _aLi, D.-Y. |
| 700 | 1 | 2 | _aLiu, X.-N. |
| 700 | 1 | 2 | _aGuo, W. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1VF3upb-Q5WmRlXzpBQ71ybXzY9XX_-9I/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
| 942 |
_2Loc _cREF1 |
||
| 008 | 250602s9999 xx |||||s2 |||| ||und|d | ||
| 999 |
_c55567 _d55567 |
||