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090			_aB-21662
245	1	0	_aPristine and artificially-aged polystyrene microplastic particles differ in regard to cellular response
490	0		_aJournal of Hazardous Materials, 435, p.128955, 2022
500			_aArtículo
520	3		_aMicroplastic particles (MP), arising from the gradual decomposition of plastics in the environment, have been identified as a global problem. Most investigations of MP cytotoxicity use pristine spherical particles available from commercial sources when evaluating their impact on mammalian cells, while only limited data is available for the more relevant "weathered microplastic". In this study, we exposed murine macrophages to polystyrene MP either after up to 130 days of accelerated ageing or in pristine condition. Weathered and pristine MP were physicochemically characterized, and their cytotoxicity was investigated using biological assays, transcriptome analysis, and metabolic pathways prediction. Whereas the response to pristine MP is mainly dominated by a TNFα release, sharp-edged weathered MP induce broader adverse cellular reactions. This study stresses the importance of including more realistic test particles (e.g., weathered particles) in combination with a broad range of biological assays when evaluating the potential risk of microplastic exposure.
650	1	4	_aWEATHERED PARTICLES
650	1	4	_aFRAGMENTS
650	1	4	_aCYTOTOXICITY
650	1	4	_aBIOLOGICAL EFFECTS
650	1	4	_aINFLAMMATION
650	1	4	_aGENOTOXICITY
650	1	4	_aTRANSCRIPTOMIC
650	1	4	_aRNA SEQUENCING
700	1	2	_aVölkl, M.
700	1	2	_aJérôme, V.
700	1	2	_aWeig, A.
700	1	2	_aJasinski, J.
700	1	2	_aMeides, N.
700	1	2	_aStrohriegl, P.:Freitag, R.
856	4	0	_uhttps://drive.google.com/file/d/13Aq4G441bcBU_vxDNv8fMldJ6afBPNzY/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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