000			01456nam a2200205Ia 4500
003			MX-MdCICY
005			20250626090915.0
040			_cCICY
090			_aB-21664
245	1	0	_aGrowth factors, matrices, and forces combine and control stem cells
490	0		_aScience, 324, p.1673, 2009
500			_aArtículo
520	3		_aStem cell fate is influenced by a number of factors and interactions that require robust control for safe and effective regeneration of functional tissue. Coordinated interactions with soluble factors, other cells, and extracellular matrices define a local biochemical and mechanical niche with complex and dynamic regulation that stem cells sense. Decellularized tissue matrices and synthetic polymer niches are being used in the clinic, and they are also beginning to clarify fundamental aspects of how stem cells contribute to homeostasis and repair, for example, at sites of fibrosis. Multifaceted technologies are increasingly required to produce and interrogate cells ex vivo, to build predictive models, and, ultimately, to enhance stem cell integration in vivo for therapeutic benefit.
700	1	2	_aDischer, D. E.
700	1	2	_aMooney, D. J.
700	1	2	_aZandstra, P. W.
856	4	0	_uhttps://drive.google.com/file/d/1kq9AdXurXWjJF5WI6iZPQ1i72lL-97sN/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
942			_2Loc _cREF1
008			250602s9999 xx |||||s2 |||| ||und|d
999			_c55730 _d55730