000			02657nam a2200313Ia 4500
003			MX-MdCICY
005			20250626090915.0
040			_cCICY
090			_aB-21683
245	1	0	_aAIDS-related cytomegalovirus encephalitis in the late ART era: A retrospective cohort study at a referral center in Brazil
490	0		_aInternational journal of STD & AIDS, 34(4), 229-235, 2023
500			_aArtículo
520	3		_aBackground: AIDS-related cytomegalovirus (CMV) encephalitis has declined in the combined antiretroviral therapy (ART) era in high-income countries. However, there is scarce information on CMV encephalitis in low- and middle-income countries. The objectives of this study were to identify the prevalence of AIDS-related CMV encephalitis and describe its main features. Methods: This was a retrospective cohort study carried out at a referral center in São Paulo, Brazil. We included adult people living with HIV/AIDS (PLWHA), hospitalized in 2019, with a CD4 cell count ≤100/mm3 and quantitation CMV DNA results in plasma. Cases with compatible neurological manifestations and detection of CMV DNA by polymerase chain reaction (PCR) in cerebrospinal fluid samples were defined as CMV encephalitis. Results: Among 761 PLWHA hospitalized, 248 (32.5 percent) cases were included in this study. Prevalence of CMV encephalitis was 2.4 percent (6/248) among all included cases and 7.7 percent (6/78) among individuals with neurological opportunistic diseases. The six patients with CMV encephalitis were males and had CD4 cell count 50,000 UI/mL plasma. All six cases received anti-CMV therapy (ganciclovir, n = 4; ganciclovir plus foscarnet, n = 2) and five were discharged to home. CMV encephalitis was not uncommon among hospitalized PLWHA with neurological opportunistic diseases. Conclusions: The epidemiological and immunological profile of individuals with CMV encephalitis was similar to that described in the pre-ART era, but in contrast, most cases were treated and discharged from the hospital.
650	1	4	_aCYTOMEGALOVIRUS
650	1	4	_aENCEPHALITIS
650	1	4	_aEPIDEMIOLOGY
650	1	4	_aDIAGNOSIS
650	1	4	_aHIGHLY ACTIVE ANTIRETROVIRAL THERAPY
650	1	4	_aBRAZIL
700	1	2	_aLucas Júnior, R. M.
700	1	2	_aBogoni, G.
700	1	2	_aReis Schneider, G. A.
700	1	2	_aCastanheira de Souza, N. F.
700	1	2	_aCarvalho, M. K.
700	1	2	_aVidal, J. E.
856	4	0	_uhttps://drive.google.com/file/d/1JMw83Qcg0rdFa_KzhC87JU71XUL0l9Ku/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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