000			01881nam a2200253Ia 4500
003			MX-MdCICY
005			20250626090917.0
040			_cCICY
090			_aB-21760
245	1	0	_aE3 ubiquitin ligase IPI1 controls rice immunity and flowering via both E3 ligase-dependent and -independent pathways
490	0		_aDevelopmental Cell, 59(20), p.2719-2730.e4, 2024
500			_aArtículo
520	3		_aImmunity and flowering are energy-consuming processes. However, the mechanism underlying the balance between immunity and flowering remains to be elucidated. Here, we report that the E3 ligase ideal plant architecture 1 interactor 1 (IPI1) controls rice immunity and flowering via two different pathways, one dependent on and another independent of its E3 ligase activity. We found that IPI1, a RING-finger E3 ligase, interacts with another E3 ligase, AvrPiz-t-interacting protein 6 (APIP6), and protects APIP6 from degradation by preventing APIP6's self-ubiquitination. Stabilization of APIP6 by IPI1 requires no IPI1 E3 ligase activity and leads to degradation of APIP6 substrates via the ubiquitin-proteasome system (UPS). Meanwhile, IPI1 directly ubiquitinates OsELF3-1 and OsELF3-2, two homologs of EARLY FLOWERING3 (ELF3), targeting them for degradation via the 26S proteasome. IPI1 knockout plants display early flowering but compromised resistance to rice blast. Thus, IPI1 balances rice immunity and flowering via both E3 ligase-dependent and -independent pathways.
700	1	2	_aYi, H.
700	1	2	_aShi, H.
700	1	2	_aMao, W.
700	1	2	_aYin, J.
700	1	2	_aMa, Y.
700	1	2	_aXu, L.
700	1	2	_aWang, J.
856	4	0	_uhttps://drive.google.com/file/d/1tsDvrwFGLVP8bSspW_fmjS4y_1-J_rfs/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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