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003			MX-MdCICY
005			20250626093125.0
040			_cCICY
090			_aB-21763
245	1	0	_aChemical Variation and Biological Properties of the Essential Oil and Main Volatiles of Pimenta dioica Harvested in the Northern Highlands of Puebla, Mexico
490	0		_aChemistry & Biodiversity, https://doi.org/10.1002/cbdv.202402843
500			_aArtículo
520	3		_aThe chemical variation of the annual essential oils from Pimenta dioca (PdEOs) grown in the Northern Highlands of Puebla, Mexico, and their biological activities were determined. Eugenol (>50 percent) and beta-myrcene (>16 percent) were the main volatiles contained in the annual PdEOs (2022-2024) extracted from fruit and leaves. PdEOs showed inhibitory properties on human pancreatic lipase (IC50, 33-44 µg/mL) through mixed type inhibition with clear eugenol involvement (IC50, 47 µg/mL). The oral administration of PdEOs and eugenol combined with corn oil on ICR mice (p < 0.01), confirmed a strong anti-hypertriglyceridemic activity at 3 and 4.5 h post-treatment. PdEOs showed low toxicity in 3T3 fibroblasts and probiotics (IC50 >500 µg/mL), whereas high lethal dose in ICR mice (LD50 >8000 mg/kg BW). Eugenol, beta-myrcene and PdEOs decreased Helicobacter pylori viability acting as mixed inhibitors on urease. Results of anti-lipase and anti-H.pylori urease assays were endorsed by docking calculations.
650	1	4	_aANTI-HELICOBACTER PYLORI
650	1	4	_aANTI-LIPASE
650	1	4	_aBETA-MYRCENE
650	1	4	_aESSENTIAL OIL
650	1	4	_aEUGENOL
650	1	4	_aPIMENTA DIOICA
700	1	2	_aPacheco-Hernández, Y.
700	1	2	_aRangel-Galván, M.
700	1	2	_aVelásquez-Hernández, F. E.
700	1	2	_aLozoya-Gloria, E.
700	1	2	_aCastro-Juárez, C. J.
700	1	2	_aVilla-Ruano, N.
856	4	0	_uhttps://drive.google.com/file/d/1eYJSfqIQUz5YAheTmUTCYzw1KpBaT8UC/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx
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