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| 003 | MX-MdCICY | ||
| 005 | 20250626093125.0 | ||
| 040 | _cCICY | ||
| 090 | _aB-21767 | ||
| 245 | 1 | 0 | _aCurbing Key Digestive Enzymes by Three Plant Extracts for Sustainable Management of Postprandial Hyperglycemia |
| 490 | 0 | _aLetters in Drug Design & Discovery, 21(11), p.2015-2022, 2024 | |
| 500 | _aArtículo | ||
| 520 | 3 | _aAbstract: Background: Diabetes mellitus is a chronic metabolic condition marked by persistently elevated blood sugar levels. Key digestive enzymes viz. α-amylase and α-glucosidase, hydrolyze consumed carbohydrates into glucose which raises the postprandial blood glucose level in a diabetic patient. So, the development of α-amylase and α-glucosidase inhibitors procured from medicinal plants to retard starch digestion is an alternative approach for controlling type 2 diabetes mellitus. Objective: The current study aimed to evaluate the inhibitory potentials of the key digestive enzymes viz. α-amylase and α-glucosidase by the extracts of three medicinal plants; red dragon fruit (Hylocereus polyrhizus) pulp and peel, bamboo (Bambusa vulgaris) shoot, turnip (Brassica rapa L.) shoot and leaf by performing α-amylase and α-glucosidase inhibition assays in vitro. Methods: Inhibition of α-amylase activity was conducted using 3,5-dinitrosalicylic acid method, and 4- Nitrophenyl-α-D-glucopyranoside was used as a substrate to perform α-glucosidase inhibition assay in vitro. Results: Among all the selected sample extracts, red dragon fruit pulp expressed the highest percentage of α-amylase inhibition (59.73 ± 4.33 percent) at the concentration of 1000 µg/mL which is comparable to standard antidiabetic drug Acarbose (70.59 ± 2.64 percent), whereas the lowest inhibition was observed in turnip shoot extract (42.48 ± 2.10 percent) at the same concentration. In terms of α-glucosidase inhibition activity, again, red dragon fruit pulp extract demonstrated the maximum inhibition rate (56.42 ± 2.38 percent) at 1000 µg/mL concentration. This is respectable in comparison to the reference Acarbose (66.45 ± 1.78 percent). In contrast, turnip shoot extracts displayed the lowest α-glucosidase inhibition activity (38.27 ± 2.21 percent) at the same concentration. Conclusion: The current study demonstrated that the red dragon fruit pulp extract possesses substantial antihyperglycemic activity (α-amylase inhibition: 59.73 ± 4.33 percent, α-glucosidase inhibition: 56.42 ± 2.38 percent) in vitro, which could be a putative nutraceutical to manage postprandial hyperglycemia. | |
| 650 | 1 | 4 | _aDIABETES MELLITUS |
| 650 | 1 | 4 | _aPOSTPRANDIAL HYPERGLYCEMIA |
| 650 | 1 | 4 | _aANTIDIABETIC ACTIVITY |
| 650 | 1 | 4 | _aΑ-AMYLASE |
| 650 | 1 | 4 | _aΑ-GLUCOSIDASE |
| 650 | 1 | 4 | _aACARBOSE |
| 650 | 1 | 4 | _aHYLOCEREUS POLYRHIZUS |
| 650 | 1 | 4 | _aBAMBUSA VULGARIS |
| 650 | 1 | 4 | _aBRASSICA RAPA L. |
| 700 | 1 | 2 | _aSarker, P. |
| 700 | 1 | 2 | _aSani, D. H. |
| 700 | 1 | 2 | _aMiah, M. F. |
| 700 | 1 | 2 | _aAlam, M. J. |
| 856 | 4 | 0 |
_uhttps://drive.google.com/file/d/1MnOLMWFrfafEBzcXqTiFHgZpiRAZrqCE/view?usp=drive_link _zPara ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx |
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