000			03458nam a22004575i 4500
001			978-0-387-09463-2
003			DE-He213
005			20260127110420.0
007			cr nn 008mamaa
008			110402s2009 xxu| s |||| 0|eng d
020			_a9780387094632
020			_a99780387094632
024	7		_a10.1007/978-0-387-09463-2 _2doi
040			_cCICY
100	1		_aFuqua, Suzanne A. W. _eeditor.
245	1	0	_aHormone Receptors in Breast Cancer _h[recurso electrónico] / _cedited by Suzanne A. W. Fuqua.
264		1	_aBoston, MA : _bSpringer US, _c2009.
300			_aX, 282p. 32 illus., 27 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCancer Treatment and Research, _x0927-3042 ; _v147
505	0		_aHormone Action and Clinical Significance of the Estrogen Receptor α -- Role of ERβ in Clinical Breast Cancer -- Hormone Action and Breast Cancer -- Estrogen Receptors in Breast Tumors of African American Patients -- BRCA1 Cross-Talk with Hormone Receptors -- Metastasis of Hormone Receptor Positive Breast Cancer -- Endocrine Therapy with Selective Estrogen Receptor Modulators (SERMs) and Aromatase Inhibitors in the Prevention and Adjuvant Therapy Settings -- Biomarkers in Neoadjuvant Trials -- Hormone Resistance -- Strategies of Hormonal Prevention -- Estrogen Receptor Phenotypes Defined by Gene Expression Profiling.
520			_aThis book provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has led to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. Hormone Receptors in Breast Cancer focuses on providing this communication. "Hormones play an essential role in both the development of breast cancer and its therapy. This text provides a comprehensive review of the key receptors and signaling pathways that effect breast cancer growth leading figures in the field provide insight into the basic biology and clinical issues relevant to this devastating disease." Steven T. Rosen, MD, Series Editor
650		0	_aMEDICINE.
650		0	_aENDOCRINOLOGY.
650		0	_aHEMATOLOGY.
650		0	_aONCOLOGY.
650	1	4	_aMEDICINE & PUBLIC HEALTH.
650	2	4	_aONCOLOGY.
650	2	4	_aHEMATOLOGY.
650	2	4	_aENDOCRINOLOGY.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387094625
830		0	_aCancer Treatment and Research, _x0927-3042 ; _v147
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-09463-2 _zVer el texto completo en las instalaciones del CICY
942			_2ddc _cER
999			_c55928 _d55928