000			03647nam a22004575i 4500
001			978-0-387-09568-4
003			DE-He213
005			20250710083923.0
007			cr nn 008mamaa
008			100301s2009 xxu| s |||| 0|eng d
020			_a9780387095684 _a99780387095684
024	7		_a10.1007/978-0-387-09568-4 _2doi
082	0	4	_a614.5999 _223
100	1		_aPotter, John D. _eeditor.
245	1	0	_aGenetics of Colorectal Cancer _h[recurso electrónico] / _cedited by John D. Potter, Noralane M. Lindor.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2009.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aCancer Genetics
505	0		_aEpidemiology and Models of Colorectal Cancer -- Colorectal Cancer: Epidemiology -- Mouse Models of Intestinal Cancer -- Pathways to Colorectal Cancer -- The Chromosomal-Instability Pathway and APC Gene Mutation in Colorectal Cancer -- DNA Methylation in Colorectal Cancer: Multiple Facets of Tumorigenesis -- Pathways and Pathology -- Germline Susceptibility - Mendelian and Other Syndromes -- Familial Adenomatous Polyposis -- DNA Mismatch Repair and Lynch Syndrome -- Additional Syndromes with Hereditary Predisposition to Colorectal Cancer -- Familial Colorectal Cancer Type X -- Families with Serrated Neoplasia of the Colon -- Peutz-Jeghers Syndrome -- Juvenile Polyposis -- BLM Mutation and Colorectal Cancer Susceptibility -- The Role of p53 in Colorectal Cancer -- Chromosomes 8q24 and 9p24: Associations with Colorectal Cancer -- Germline Susceptibility - Gene-Environment Interactions -- Genetic Variability in Folate-Mediated One-Carbon Metabolism and Risk of Colorectal Neoplasia -- Genetic Variability in NSAID Targets and NSAID-Metabolizing Enzymes and Colorectal Neoplasia -- The Role of Chemical Carcinogens and Their Biotransformation in Colorectal Cancer -- Calcium and Vitamin D.
520			_aThe last 20 years have seen a remarkable increase in knowledge of the etiology of colorectal cancer. At least three aspects are much clearer. First, known environmental agents and behaviors have been identified that increase risk (for example, diets high in meat, obesity, and smoking ) or decrease risk (for example, diets high in plant foods, aspirin, and physical activity) of colorectal cancer. Second, germline mutations in specific genes have been identified for the major inherited syndromes involving colorectal cancer (FAP, Lynch Syndrome, Juvenile Polyposis, MYH-Associated Polyposis, Li-Fraumeni Syndrome) as have variants of genes that modify the risk associated with the known environmental agents. Third, the specific tissue, cellular, and molecular disturbances that characterize the progression to different subtypes of colorectal cancer have been recently described. Genetics of Colorectal Cancer provides the most up-to-date information in each of these areas.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aHUMAN GENETICS.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aHUMAN GENETICS.
650	2	4	_aONCOLOGY.
700	1		_aLindor, Noralane M. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387095677
830		0	_aCancer Genetics
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-09568-4 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c55974 _d55974