000			03251nam a22004335i 4500
001			978-0-387-09581-3
003			DE-He213
005			20250710083923.0
007			cr nn 008mamaa
008			101029s2011 xxu| s |||| 0|eng d
020			_a9780387095813 _a99780387095813
024	7		_a10.1007/978-0-387-09581-3 _2doi
082	0	4	_a614.5999 _223
100	1		_aDudley, Jaquelin. _eeditor.
245	1	0	_aRetroviruses and Insights into Cancer _h[recurso electrónico] / _cedited by Jaquelin Dudley.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2011.
300			_aXII, 363p. 44 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_a1. Mouse mammary tumor virus -- 2. Jaagsiekte sheep retrovirus -- 3. Avian leukosis virus -- 4. Abelson murine leukemia virus -- 5. Human T-cell leukemia virus -- 6. Feline leukemia virus -- 7. Murine leukemia virus -- 8. Spleen focus-forming virus -- 9. Koala retrovirus -- 10. Human immunodeficiency virus.
520			_aRetroviruses cause chronic infections and insertion mutations in their hosts, often leading to the appearance of tumors. Studies of retrovirus-induced tumors have led to our understanding of many crucial concepts in cell and cancer biology, including the discoveries of reverse transcriptase, viral oncogenes, cellular proto-oncogenes and signal transduction pathways. This monograph provides an intriguing set of chapters on the many facets of retroviral involvement in cancers arising in a variety of organisms from fish to humans. Each chapter is written by experts in the field and relates recent work to previous experimental data. Retroviruses use many different mechanisms to induce cancers, ranging from activation of microRNAs, inactivation of tumor suppressor genes, activation or modifications of proto-oncogenes, as well as expression of viral proteins that manipulate cell signaling and the immune system. In recent years, retroviruses have been used as tools, not only for the characterization of cellular pathways, but also as vectors to deliver therapeutic or engineered genes. This knowledge is all the more startling due to the revelation that nearly 10% of the human genome consists of endogenous retroviruses, including many that are transcriptionally active. The emergence of new endogenous retroviruses causing lethal leukemias in koalas and, potentially, prostate cancer in humans ensures that the unique interactions of these viruses with their hosts will continue to fascinate and illuminate us.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aMICROBIOLOGY.
650		0	_aMEDICAL VIROLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aVIROLOGY.
650	2	4	_aMEDICAL MICROBIOLOGY.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387095806
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-09581-3 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c55979 _d55979