000			03664nam a22004095i 4500
001			978-0-387-09597-4
003			DE-He213
005			20250710083923.0
007			cr nn 008mamaa
008			100301s2009 xxu| s |||| 0|eng d
020			_a9780387095974 _a99780387095974
024	7		_a10.1007/978-0-387-09597-4 _2doi
082	0	4	_a611.01816 _223
100	1		_aCheng, C. Yan. _eeditor.
245	1	0	_aMolecular Mechanisms in Spermatogenesis _h[recurso electrónico] / _cedited by C. Yan Cheng.
264		1	_aNew York, NY : _bSpringer New York, _c2009.
300			_aXVII, 274 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v636
505	0		_aSpermatogenesis and Cycle of the Seminiferous Epithelium -- Testicular Development and Spermatogenesis: Harvesting the Postgenomics Bounty -- Estrogens and Spermatogenesis -- Selenium, a Key Element in Spermatogenesis and Male Fertility -- Extracellular Matrix and Its Role in Spermatogenesis -- Inflammatory Networks in the Control of Spermatogenesis -- Transcription Regulation in Spermatogenesis -- Proteases and Their Cognate Inhibitors of the Serine and Metalloprotease Subclasses, in Testicular Physiology -- Antioxidant Systems and Oxidative Stress in the Testes -- Nitric Oxide and Cyclic Nucleotides: Their Roles in Junction Dynamics and Spermatogenesis -- The Sertoli Cell Cytoskeleton -- Blood-Testis Barrier, Junctional and Transport Proteins and Spermatogenesis -- Cross-Talk between Tight and Anchoring Junctions-Lesson from the Testis -- The Role of the Leydig Cell in Spermatogenic Function.
520			_aIn the past thirty years, significant advances have been made in the field of reproductive biology in unlocking the molecular and biochemical events that regulate spermatogenesis in the mammalian testis. It was possible because of the unprecedented breakthroughs in molecular biology, cell biology, immunology, and biochemistry. In this book entitled, Molecular Mechanisms in Spermatogenesis, a collection of chapters has been included written by colleagues on the latest development in the field using genomic and proteomic approaches to study spermatogenesis, as well as different mechanisms and/or molecules including environmental toxicants and transcription factors that regulate and/or affect spermatogenesis. The book begins with a chapter that provides the basic concept of cellular regulation of spermatogenesis. A few chapters are also dedicated to some of the latest findings on the Sertoli cell cytoskeleton and other molecules (e.g., proteases, adhesion proteins) that regulate spermatogenesis. These chapters contain thought-provoking discussions and concepts which shall be welcomed by investigators in the field. It is obvious that many of these concepts will be updated and some may be amended in the years to come. However, they will serve as a guide and the basis for investigation by scientists in the field.
650		0	_aMEDICINE.
650	1	4	_aBIOMEDICINE.
650	2	4	_aMOLECULAR MEDICINE.
650	2	4	_aBIOMEDICINE GENERAL.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387799902
830		0	_aAdvances in Experimental Medicine and Biology, _x0065-2598 ; _v636
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-09597-4 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c55983 _d55983