000			03161nam a22004695i 4500
001			978-0-387-09637-7
003			DE-He213
005			20250710083924.0
007			cr nn 008mamaa
008			100715s2009 xxu| s |||| 0|eng d
020			_a9780387096377 _a99780387096377
024	7		_a10.1007/978-0-387-09637-7 _2doi
082	0	4	_a614.5999 _223
100	1		_aMaragoudakis, Michael E. _eeditor.
245	1	0	_aThrombin _h[recurso electrónico] : _bPhysiology and Disease / _cedited by Michael E. Maragoudakis, Nikos E. Tsopanoglou.
264		1	_aNew York, NY : _bSpringer New York : _bImprint: Springer, _c2009.
300			_aVIII, 240p. 46 illus., 23 illus. in color. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aThrombin: Structure, Functions, and Regulation -- Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation -- Regulation of Thrombin Receptor Signaling -- Thrombin-Activated Protein C: Integrated to Regulate Vascular Physiology -- The Role of Thrombin in Vascular Development -- The Role of Thrombin in Angiogenesis -- Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair -- The Role of Thrombin and Thrombin Receptors in the Brain -- The Role of Thrombin in Tumor Biology -- The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation -- Anti-thrombotic Therapy in Cancer Patients -- Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application -- Novel Anticoagulant Therapy: Principle and Practice.
520			_aIt has become increasingly evident in recent years that, apart from the key role that thrombin plays in the blood coagulation cascade, thrombin also elicits cellular actions via the activation of proteinase-activated receptors, which are present in many cell types. These effects of thrombin are seen in a variety of physiological as well as pathological phenomena, including vascular development and physiology, tumor progression and metastasis, neuronal functions, inflammation, angiogenesis. Thrombin: Physiology and Disease, edited by Michael E. Maragoudakis and Nikos E. Tsopanoglou, emphasizes the new developments in this important field of research and provides the basis for translating these findings into therapeutic targets."
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aTOXICOLOGY.
650		0	_aEPIDEMIOLOGY.
650		0	_aBIOCHEMISTRY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aPHARMACOLOGY/TOXICOLOGY.
650	2	4	_aBIOCHEMISTRY, GENERAL.
650	2	4	_aEPIDEMIOLOGY.
700	1		_aTsopanoglou, Nikos E. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387096360
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-09637-7 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c56001 _d56001