000 04406nam a22004455i 4500
001 978-0-387-23226-3
003 DE-He213
005 20250710083927.0
007 cr nn 008mamaa
008 100301s2005 xxu| s |||| 0|eng d
020 _a9780387232263
_a99780387232263
024 7 _a10.1007/b100942
_2doi
082 0 4 _a572
_223
100 1 _aHarris, J. Robin.
_eeditor.
245 1 0 _aAlzheimer's Disease
_h[recurso electrónico] :
_bCellular and Molecular Aspects of Amyloid β /
_cedited by J. Robin Harris, Falk Fahrenholz.
264 1 _aBoston, MA :
_bSpringer US,
_c2005.
300 _aXVII, 409 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aSubcellular Biochemistry,
_x0306-0225 ;
_v38
505 0 _aThe Contribution of Microscopy to the Study of Alzheimer's Disease, Amyloid Plaques and A? Fibrillogenesis -- Transgenic Mouse Models for APP Processing and Alzheimer's Disease: Early and Late Defects -- Oxidative stress in Alzheimer's Disease: Implications for Prevention and Therapy -- ?-Secretase, APP and A? in Alzheimer's Disease -- The Non-Amyloidogenic Pathway: Structure and Function of ?-Secretases -- Amyloid ? Degradation: A Challenging Task for Brain Peptidases -- The Protective Role of Vitamin E in Vascular Amyloid ?-Mediated Damage -- Amyloid Accumulation and Pathogensis of Alzheimer's Disease: Significance of Monomeric, Oligomeric and Fibrillar A? -- Cholesterol and Amyloid ? Fibrillogenesis -- Alzheimer's ?-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding -- The Aluminium-Amyloid Cascade Hypothesis and Alzheimer's Disease -- Amyloid-? Metal Interaction and Metal Chelation -- The Interaction of Amyloid-? with ApoE -- Clusterin and Alzheimer's Disease -- Acetylcholinesterase Interaction with Alzheimer Amyloid ? -- Membrane Disordering Effects of ?-Amyloid Peptides -- The Role of Alzheimer A? Peptides in Ion Transport Across Cell Membranes -- Amyloid Inhibitors and ?-Sheet Breakers -- Cholesterol and Alzheimer's Disease: Statins, Cholesterol Depletion in APP Processing and A? Generation -- Phosphorylated Amyloid-?: the Toxic Intermediate in Alzheimer's Disease Neurodegeneration.
520 _aThis book contains a survey of present-day research into the biomedical fundamentals of Alzheimer's disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy) have made since the seminal light microscopical studies of Alois Alzheimer, the book presents chapters on specialist topics:- transgenic mouse models of AD; the enzymology of amyloid-ß production and degradation; oxidant stress and antioxidant protection; the involvement of metal ions and the influence of chelators; the importance of amyloid-ß oligomers and fibrils, the role of cholesterol in their formation and characteristic binding of the dye Congo red; of the many AD plaque-associated proteins, ApoE4 , clusterin and acetylcholinesterase receive individual attention; the effect of amyloid-ß on neuronal membrane calcium channels and membrane fluidity are covered, as are drug interactions, the ß-sheet breaking peptides and the statins that may prevent oligomer/fibril formation in AD; the possible significance of amyloid-ß phosphorylation receives detailed attention. Overall, the book contains a broad range of current information on cellular, biochemical and structural aspects of amyloid-ß, of direct relevance to Alzheimer's disease.
650 0 _aLIFE SCIENCES.
650 0 _aNEUROSCIENCES.
650 0 _aBIOCHEMISTRY.
650 1 4 _aLIFE SCIENCES.
650 2 4 _aBIOCHEMISTRY, GENERAL.
650 2 4 _aNEUROSCIENCES.
700 1 _aFahrenholz, Falk.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387232256
830 0 _aSubcellular Biochemistry,
_x0306-0225 ;
_v38
856 4 0 _uhttp://dx.doi.org/10.1007/b100942
_zVer el texto completo en las instalaciones del CICY
912 _aZDB-2-SBL
942 _2ddc
_cER
999 _c56157
_d56157