000			03482nam a22004935i 4500
001			978-0-387-23923-1
003			DE-He213
005			20250710083930.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9780387239231 _a99780387239231
024	7		_a10.1007/b103635 _2doi
082	0	4	_a612.8 _223
100	1		_aBrown, David R. _eeditor.
245	1	0	_aNeurodegeneration and Prion Disease _h[recurso electrónico] / _cedited by David R. Brown.
264		1	_aBoston, MA : _bSpringer US, _c2005.
300			_aXV, 473 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aNeuropathology of Transmissible Spongiform Encephalopathies (Prion Diseases) -- Central Pathogenesis of Prion Diseases -- Hereditary Prion Protein Amyloidoses -- Mouse Behavioural Studies and What They Can Teach Us about Prion Diseases -- Electrophysiological Approaches to the Study of Prion Diseases -- Prion Protein, Prion Protein-Like Protein, and Neurodegeneration -- Oxidative Stress and Mitochondrial Dysfunction in Neurodegeneration of Transmissible Spongiform Encephalopathies (TSEs) -- Mechanisms of Prion Toxicity and Their Relationship to Prion Infectivity -- A Stone Guest on the Brain: Death as a Prion -- Molecular Mechanisms Mediating Neuronal Cell Death in Experimental Models of Prion Diseases, in vitro -- Processing and Mis-Processing of the Prion Protein: Insights into the Pathogenesis of Familial Prion Disorders -- Signaling Pathways Controling Prion Neurotoxicity: Role of Endoplasmic Reticulum Stress-Mediated Apoptosis -- Cell Culture Models to Unravel Prion Protein Function and Aberrancies in TSE -- Insights into the Cellular Trafficking of Prion Proteins -- The Molecular Basis of Prion Protein-Mediated Neuronal Damage -- Conclusion: Intervention, the Final Frontier.
520			_aThis volume provides an in-depth overview from world experts on prion disease. These fatal diseases include Creutzfeldt-Jakob disease, chronic wasting disease in deer, scrapie of sheep, bovine spongiform encephalopathy (mad cow's disease) of cattle and related diseases. Understanding what causes neuronal death in these diseases is essential to both preventing and curing them. The most recent advances in understanding neuronal death in prion diseases are presented. Prion diseases serve as an experimental model for all neurodegenerative conditions. This book will provide understanding of neurodegeneration and provide an up-to-date record of the state of the art for other specialists and non-specialists in related fields.
650		0	_aMEDICINE.
650		0	_aNEUROSCIENCES.
650		0	_aNEUROLOGY.
650		0	_aVETERINARY MEDICINE.
650		0	_aBIOCHEMISTRY.
650		0	_aPHYSIOLOGY _xMATHEMATICS.
650	1	4	_aBIOMEDICINE.
650	2	4	_aNEUROSCIENCES.
650	2	4	_aPHYSIOLOGICAL, CELLULAR AND MEDICAL TOPICS.
650	2	4	_aNEUROLOGY.
650	2	4	_aBIOCHEMISTRY, GENERAL.
650	2	4	_aVETERINARY MEDICINE.
650	2	4	_aMOLECULAR MEDICINE.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387239224
856	4	0	_uhttp://dx.doi.org/10.1007/b103635 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c56281 _d56281