000			04520nam a22004815i 4500
001			978-0-387-25240-7
003			DE-He213
005			20250710083933.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9780387252407 _a99780387252407
024	7		_a10.1007/b106967 _2doi
082	0	4	_a570.285 _223
100	1		_aVaidyanathan, Seetharaman. _eeditor.
245	1	0	_aMetabolome Analyses: Strategies for Systems Biology _h[recurso electrónico] / _cedited by Seetharaman Vaidyanathan, George G. Harrigan, Royston Goodacre.
264		1	_aBoston, MA : _bSpringer US, _c2005.
300			_aXXII, 394p. 74 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aTowards Integrative Functional Genomics Using Yeast as a Reference Model -- Metabolomics for the Assessment of Functional Diversity and Quality Traits in Plants -- Metabolomics: A New Approach Towards Identifying Biomarkers and Therapeutic Targets in CNS Disorders -- Comparative Metabolome Profiling Using Two Dimensional Thin Layer Chromatography (2DTLC) -- Capillary Electrophoresis and Its Application in Metabolome Analysis -- Metabolite Profiling with GC-MS and LC-MS -- The Application of Electrochemistry to Metabolic Profiling -- Differential Metabolic Profiling for Biomarker Discovery -- NMR-Based Metabonomics in Toxicology Research -- Methodological Issues and Experimental Design Considerations in Metabolic Profile-Based Classifications -- Modelling of Fungal Metabolism -- Detailed Kinetic Models Using Metabolomics Data Sets -- Metabolic Networks -- Metabolic Networks from a Systems Perspective -- Parallel Metabolite and Transcript Profiling -- Fluxome Profiling in Microbes -- Targeted Drug Design and Metabolic Pathway Flux -- Metabonomics in the Pharmaceutical Industry -- How Lipidomic Approaches Will Benefit the Pharmaceutical Industry -- Metabolites and Fungal Virulence.
520			_aMetabolome Analyses is intended as a follow-up to Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis (Kluwer, 2003). That text offered guidelines to currently available technology, bioinformatics and databases. Evidence was presented showing metabolic profiling as a valuable addition to genomics and proteomics strategies devoted to drug discovery and development. This book focuses on how metabolic profiling is being more comprehensively integrated with the other "omics" technologies. It provides more practical applications of such "panomics" or "Systems Biology" approaches. The expanding use of mass spectrometry as a measurement technology in metabolic profiling is addressed through demonstrated applications. The integration of metabolic profiling and proteomics is probably most developed for plant-based studies, which was not addressed in Volume 1. Other areas related to metabolic profiling continue to show significant development. These include database strategies and an increased acceptance by the pharmaceutical industry of metabolic profiling. Also covered is the use of in silico metabolic networks. Again the focus is primarily on the pharmaceutical industry but the importance of metabolic profiling to studies on human nutrition (a burgeoning area) is discussed. The primary audience for Metabolome Analyses consists of academics (professors, post-doctoral researchers) involved in metabolic analyses, genomics transcriptomics, proteomics, bioinformatics; and corresponding researchers in the pharmaceutical and biotechnology industries (including Big Pharma, mid -capital and small venture-capital based enterprises) and in research institutes.
650		0	_aLIFE SCIENCES.
650		0	_aANALYTICAL BIOCHEMISTRY.
650		0	_aINTERNAL MEDICINE.
650		0	_aBIOCHEMISTRY.
650		0	_aBIOINFORMATICS.
650	1	4	_aLIFE SCIENCES.
650	2	4	_aBIOINFORMATICS.
650	2	4	_aINTERNAL MEDICINE.
650	2	4	_aANALYTICAL CHEMISTRY.
650	2	4	_aBIOCHEMISTRY, GENERAL.
700	1		_aHarrigan, George G. _eeditor.
700	1		_aGoodacre, Royston. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387252391
856	4	0	_uhttp://dx.doi.org/10.1007/b106967 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c56412 _d56412