000			03823nam a22004455i 4500
001			978-0-387-25446-3
003			DE-He213
005			20250710083933.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9780387254463 _a99780387254463
024	7		_a10.1007/b107412 _2doi
082	0	4	_a612.8 _223
100	1		_aLecea, Luis. _eeditor.
245	1	0	_aHypocretins _h[recurso electrónico] : _bIntegrators of Physiological Functions / _cedited by Luis Lecea, J. Gregor Sutcliffe.
264		1	_aBoston, MA : _bSpringer US, _c2005.
300			_aXXIII, 439 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aDiscovery of the Hypocretins/Orexins and Their Receptors -- The Discovery of the Hypocretins -- Orexin and Orexin Receptors -- Animal Models in the Study of the Hypocretinergic System -- Rodent Models of Human Narcolepsy-cataplexy -- The Canine Model of Narcolepsy -- Detailed Anatomy of the Hypocretinergic System and Related Hypothalamic Circuits -- Anatomy of the Hypocretin System -- The Anatomy of Hypocretin Neurons -- Transmitter-Identified Neurons and Afferent Innervation of the Lateral Hypothalamic Area -- Physiological Consequences of Hypocretin Activation -- Physiological Characteristics of Hypocretin/Orexin Neurons -- The Ne System as a Target for Hypocretin Neurons -- Hypocretin/Orexin Actions on Mesopontine Cholinergic Systems Controling Behavioral State -- The Aminergic Systems and the Hypocretins -- Effects Of Hypocretin/Orexin on the Thalamocortical Activating System -- Pharmacology of the Hypocretins and Drug Design -- In Vivo Pharmacology of Orexin (Hypocretin) Receptors -- Intracellular Signal Pathways Utilized by the Hypocretin/Orexin Receptors -- The Hypocretins in Narcolepsy and Arousal -- The Hypocretins and Narcolepsy -- An Approach to Determining the Functions of Hypocretin (Orexin) -- Hypocretin in Neuropsychiatric Disorders -- Hypocretin/Orexin and Sleep -- Modulation of Cortical Activity and Sleep-Wake States by Hypocretin/Orexin -- The Hypocretins in Feeding and Energy Balance -- Regulation of Hypocretin by Metabolic Signals -- The Hypocretins in Addiction and Hyperarousal -- Hypocretin and Brain Reward Function -- Orexin/Hypocretin and Opioid Dependence -- Dopamine-Hypocretin/Orexin Interactions -- Hypocretin/Orexin in Stress and Arousal -- Role of Hypocretins on Peripheral Systems -- The Hypocretins/Orexins and the Hypothalamo-Pituitary-Adrenal Axis -- Orexins (Hypocretins) in the Gut -- Hypocretins in Endocrine Regulation -- The Hypocretins in Cardiovascular Regulation.
520			_aThe hypocretins (orexins) are a newly identified (1998) peptide family comprised of two peptides, hypocretin-1 and hypocretin-2. Recent observations suggest an involvement of these peptides, located primarily in the hypothalmus, in the regulation of behavioral state. They are involved in circadian rhythms, metabolism, hormone secretion, body temperature, appetite, cardiovascular functions (e.g., blood pressure), and sleep abnormalities (e.g., narcolepsy and cataplexy).
650		0	_aMEDICINE.
650		0	_aNEUROSCIENCES.
650		0	_aENDOCRINOLOGY.
650		0	_aNEUROLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aNEUROSCIENCES.
650	2	4	_aENDOCRINOLOGY.
650	2	4	_aNEUROLOGY.
700	1		_aSutcliffe, J. Gregor. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387250007
856	4	0	_uhttp://dx.doi.org/10.1007/b107412 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c56433 _d56433