000 06001nam a22004935i 4500
001 978-0-387-25518-7
003 DE-He213
005 20250710083933.0
007 cr nn 008mamaa
008 100301s2005 xxu| s |||| 0|eng d
020 _a9780387255187
_a99780387255187
024 7 _a10.1007/b135502
_2doi
082 0 4 _a616.079
_223
100 1 _aLavi, Ehud.
_eeditor.
245 1 0 _aExperimental Models of Multiple Sclerosis
_h[recurso electrónico] /
_cedited by Ehud Lavi, Cris S. Constantinescu.
264 1 _aBoston, MA :
_bSpringer US,
_c2005.
300 _aXII, 901 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
505 0 _aExperimental Allergic (Autoimmune) Encephalomyelitis (EAE) -- EAE: History, Clinical Signs, and Disease Course -- Induction of EAE -- Histopathology of EAE -- Neuroantigens in EAE -- Adjuvants in EAE -- The Role of Astrocytes in Autoimmune Disease of the Central Nervous System -- Role of Microglia and Macrophages in Eae -- The Neuron and Axon in Experimental Autoimmune Encephalomyelitis -- Endothelial Cells and Adhesion Molecules in Experimental Autoimmune Encephalomyelitis -- Genetics of Experimental Allergic Encephalomyelitis -- T Lymphocytes in EAE -- The Role of Complement in EAE -- B Cells and Antibodies in Experimental Autoimmune Encephalomyelitis -- Cytokines in Experimental Autoimmune Encephalomyelitis -- The Role of Interferons in Experimental Autoimmune Encephalomyelitis -- The Role of Growth Factors in Experimental Autoimmune Encephalomyelitis -- The Chemokine System in Experimental Autoimmune Encephalomyelitis -- Free Radicals and Experimental Autoimmune Encephalomyelitis -- Proteases and Peptidases in EAE -- The Blood-Brain Barrier in EAE -- Immunomodulation of EAE: Altered Peptide Ligands, Tolerance, and Th1/Th2 -- The Role of Costimulation in Experimental Autoimmune Encephalomyelitis -- Epitope Spreading in EAE -- Apoptotic Cell Death in Experimental Autoimmune Encephalomyelitis -- Environmental Influences in Experimental Autoimmune Encephalomyelitis -- Hormonal and Gender Influences on Experimental Autoimmune Encephalomyelitis -- Experimental Autoimmune Encephalomyelitis in Primates -- Theiler's Murine Encephalomyelitis Virus (TMEV) - Induced Demyelination -- Histopathology in the Theiler's Virus Model of Demyelination -- TMEV and Neuroantigens: Myelin Genes and Proteins, Molecular Mimicry, Epitope Spreading, and Autoantibody-Mediated Remyelination -- The Role of Astrocytes, Oligodendrocytes, Microglia and Endothelial Cells in TMEV Infection -- Immunogenetics, Resistance, and Susceptibility to Theiler's Virus Infection -- The Role of T Cells and the Innate Immune System in the Pathogenesis of Theiler's Virus Demyeliating Disease -- Cytokines, Chemokines and Adhesion Molecules in TMEV-IDD -- Molecular Determinants of TMEV Pathogenesis -- Nitric Oxide in TMEV -- Theiler's Murine Encephalomyelitis Virus (TMEV)-Induced Demyelination -- Corona Virus-Induced Demyelination -- Histopathology in Coronavirus-Induced Demyelination -- The Role of Astrocytes, Microglia, and Endothelial Cells in Coronavirus-Induced Demyelination -- Axons and Neurons in Corona Virus-Induced Demyelination -- The Role of T Cells in Corona-Virus-Induced Demyelination -- The Role of Humoral Immunity in Mouse Hepatitis Virus Induced Demyelination -- The Role of T Cell Epitopes in Coronavirus Infection -- Coronaviruses and Neuroantigens: myelin proteins, myelin genes -- Coronavirus-Induced Demyelination and Spontaneous Remyelination -- Chemokines in Coronavirus-Induced Demyelination -- Coronavirus Receptors -- Apoptosis in MHV-Induced Demyelination -- The Role of Metalloproteinases in Corona Virus Infection -- Molecular Determinants of Coronavirus Mhv- Induced Demyelination -- Demyelination Induced by Other Viruses -- Semliki Forest Virus Induced Demyelination -- The Pathogenesis of Canine Distemper Virus Induced Demyelination.
520 _aMultiple Sclerosis (MS) is an enigmatic immune mediated disease of the central nervous system that affects about 350,000 individuals in the US, and many more around the world. The mechanism of this disease is largely unknown and there is no cure for it. However, there are several well-characterized experimental animal models that help us understand and speculate about potential mechanisms of pathology in this disease. Many of the experimental therapies designed for this disease rely on testing the drugs in animal models before using it in clinical trials. This book combines for the first time the different experimental models for MS (including immune-mediated and viral) under one roof, and highlights aspects that are different or shared among these experimental models. It's aim is to improve our understanding of this devastating disease and help us think about potential additional therapies for it. Experimental Models of Multiple Sclerosis will be an important reference for neuroscientists, neurologists, immunologists, microbiologists (especially virologists) and pathologists (especially neuropathologists). Health professionals involved with MS, and medical students will also benefit from this book.
650 0 _aMEDICINE.
650 0 _aIMMUNOLOGY.
650 0 _aNEUROSCIENCES.
650 0 _aMEDICAL VIROLOGY.
650 0 _aNEUROLOGY.
650 0 _aPATHOLOGY.
650 1 4 _aBIOMEDICINE.
650 2 4 _aIMMUNOLOGY.
650 2 4 _aVIROLOGY.
650 2 4 _aNEUROSCIENCES.
650 2 4 _aPATHOLOGY.
650 2 4 _aNEUROLOGY.
700 1 _aConstantinescu, Cris S.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387255170
856 4 0 _uhttp://dx.doi.org/10.1007/b135502
_zVer el texto completo en las instalaciones del CICY
912 _aZDB-2-SBL
942 _2ddc
_cER
999 _c56443
_d56443