000			04549nam a22004455i 4500
001			978-0-387-25919-2
003			DE-He213
005			20250710083935.0
007			cr nn 008mamaa
008			100301s2006 xxu| s |||| 0|eng d
020			_a9780387259192 _a99780387259192
024	7		_a10.1007/b136464 _2doi
082	0	4	_a616.079 _223
100	1		_aUversky, Vladimir N. _eeditor.
245	1	0	_aProtein Misfolding, Aggregation, and Conformational Diseases _h[recurso electrónico] : _bPart A: Protein Aggregation and Conformational Diseases / _cedited by Vladimir N. Uversky, Anthony L. Fink.
264		1	_aBoston, MA : _bSpringer US, _c2006.
300			_aXVIII, 419 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aProtein Reviews ; _v4
505	0		_aStructural and Conformational Prerequisites of Amyloidogenesis -- Structural and Conformational Prerequisites of Amyloidogenesis -- The Generic Nature of Protein Folding and Misfolding -- The Generic Nature of Protein Folding and Misfolding -- Relative Importance of Hydrophobicity, Net Charge, and Secondary Structure Propensities in Protein Aggregation -- Relative Importance of Hydrophobicity, Net Charge, and Secondary Structure Propensities in Protein Aggregation -- Cytotoxic Intermediates in the Fibrillation Pathway: A? Oligomers in Alzheimer's Disease as a Case Study -- Cytotoxic Intermediates in the Fibrillation Pathway: A? Oligomers in Alzheimer's Disease as a Case Study -- Glycosaminoglycans, Proteoglycans, and Conformational Disorders -- Glycosaminoglycans, Proteoglycans, and Conformational Disorders -- Apolipoproteins in Different Amyloidoses -- Apolipoproteins in Different Amyloidoses -- Oxidative Stress and Protein Deposition Diseases -- Oxidative Stress and Protein Deposition Diseases -- Chaperone and Conformational Disorders -- Chaperone Suppression of Aggregated Protein Toxicity -- Mechanisms of Active Solubilization of Stable Protein Aggregates by Molecular Chaperones -- The Aggresome: Proteasomes, Inclusion Bodies, and Protein Aggregation -- The Aggresome: Proteasomes, Inclusion Bodies, and Protein Aggregation -- Protein Aggregation, Ion Channel Formation, and Membrane Damage -- Protein Aggregation, Ion Channel Formation, and Membrane Damage -- Visualization of Protein Deposits In Vivo -- Congo Red Staining of Amyloid: Improvements and Practical Guide for a More Precise Diagnosis of Amyloid and the Different Amyloidoses -- Immunohistological Study of Experimental Murine AA Amyloidosis -- Visualization of Protein Deposits In Vitro -- Reporters of Amyloid Structure -- Three-Dimensional Structural Analysis of Amyloid Fibrils by Electron Microscopy -- Atomic Force Microscopy -- Direct Observation of Amyloid Fibril Growth Monitored by Total Internal Reflection Fluorescence Microscopy -- Animal and Cell Models of Human Neurodegenerative Disorders -- Drosophila and C. elegans Models of Human Age-Associated Neurodegenerative Diseases -- Genetically Engineered Mouse Models of Neurodegenerative Disorders.
520			_aProtein Misfolding, Aggregation, and Conformational Disease, is the first book to discuss significant achievements in protein structure-function relationships in the areas of biochemistry, molecular biology and molecular medicine. This volume summarizes recent achievements in the understanding of the relationships between protein misfolding, aggregation and development of protein deposition disorders. Research indicates that various human disorders, including most neurodegenerative diseases, systemic amyloidoses and many others, arise from the misfolding and aggregation of an underlying protein. Protein Misfolding, Aggregation and Conformational Diseases is an ideal book for biochemists, protein scientists, immunologists, pharmaceutical scientists, and molecular and cellular biologists.
650		0	_aMEDICINE.
650		0	_aIMMUNOLOGY.
650		0	_aCYTOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aIMMUNOLOGY.
650	2	4	_aCELL BIOLOGY.
700	1		_aFink, Anthony L. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387259185
830		0	_aProtein Reviews ; _v4
856	4	0	_uhttp://dx.doi.org/10.1007/b136464 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c56508 _d56508