000 03489nam a22004575i 4500
001 978-0-387-26283-3
003 DE-He213
005 20250710083936.0
007 cr nn 008mamaa
008 100301s2006 xxu| s |||| 0|eng d
020 _a9780387262833
_a99780387262833
024 7 _a10.1007/b137303
_2doi
082 0 4 _a616.994
_223
100 1 _aDalgleish, Angus G.
_eeditor.
245 1 4 _aThe Link Between Inflammation and Cancer
_h[recurso electrónico] :
_bWounds that do not heal /
_cedited by Angus G. Dalgleish, Burkhard Haefner.
264 1 _aBoston, MA :
_bSpringer US,
_c2006.
300 _aXII, 254 p.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _arecurso en línea
_bcr
_2rdacarrier
347 _atext file
_bPDF
_2rda
490 1 _aCancer Treatment and Research,
_x0927-3042 ;
_v130
505 0 _aForeword -- Inflammation and Cancer: The role of the immune response and angiogenesis -- Chronic Inflammation and Pathogenesis of GI and Pancreatic Cancers -- Cytokines, NF-kB, Microenvironment, Intestinal Inflammation and Cancer -- Regulation of NF-kB Transcriptional Activity -- The Role of Immune Cells in the Tumor Microenvironment -- Tumor-Microenvironment Interactions: The Selectin-Selectin Ligand Axis in Tumor-Endothelium Cross Talk -- CD95L/FasL and Trail in Tumour Surveillance and Cancer Therapy -- Infection & Neoplastic Growth 101: The required reading for microbial pathogens aspiring to cause cancer -- Cytokines as Mediators and Targets for Cancer Cachexia -- Targeting NF-kB in Anticancer Adjunctive Chemotherapy -- Index.
520 _aThe transcription factor NF-kB has long been known to play a central role in the immune system by regulating the expression of key genes. Moreover, activation of this transcription factor helps a wide variety of cell types survive damage induced by pro-apoptotic stimuli. Owing to its critical role in the regulation of pro-inflammatory genes, NF-kB has long been regarded as a promising target for the discovery of anti-inflammatory drugs. More recently, NF-kB has emerged as a major culprit in a variety of human cancers mainly due to its ability to protect transformed cells from apoptosis. This finding should not have come as a surprise since there exists a link between inflammation and many types of cancer which was already suggested by Galen and later demonstrated by Virchow. This link, of crucial importance for the design of novel strategies for cancer treatment, is the topic of this book. Series Editor Cover Comments: "Inflammation is a known risk factor for a number of cancers. In this text, experts discuss the pathophysiology and molecular alterations that link these two processes. Potential therapeutics and preventive strategies are discussed." Steven T. Rosen, M.D. Series Editor
650 0 _aMEDICINE.
650 0 _aONCOLOGY.
650 0 _aMEDICAL LABORATORIES.
650 1 4 _aMEDICINE & PUBLIC HEALTH.
650 2 4 _aONCOLOGY.
650 2 4 _aCANCER RESEARCH.
650 2 4 _aLABORATORY MEDICINE.
700 1 _aHaefner, Burkhard.
_eeditor.
710 2 _aSpringerLink (Online service)
773 0 _tSpringer eBooks
776 0 8 _iPrinted edition:
_z9780387262826
830 0 _aCancer Treatment and Research,
_x0927-3042 ;
_v130
856 4 0 _uhttp://dx.doi.org/10.1007/b137303
_zVer el texto completo en las instalaciones del CICY
912 _aZDB-2-SME
942 _2ddc
_cER
999 _c56554
_d56554