| 000 | 02447nam a22003855i 4500 | ||
|---|---|---|---|
| 001 | 978-0-387-27199-6 | ||
| 003 | DE-He213 | ||
| 005 | 20250710083938.0 | ||
| 007 | cr nn 008mamaa | ||
| 008 | 100301s2006 xxu| s |||| 0|eng d | ||
| 020 |
_a9780387271996 _a99780387271996 |
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| 024 | 7 |
_a10.1007/b138744 _2doi |
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| 082 | 0 | 4 |
_a615 _223 |
| 100 | 1 |
_aBonate, Peter L. _eauthor. |
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| 245 | 1 | 0 |
_aPharmacokinetic-Pharmacodynamic Modeling and Simulation _h[recurso electrónico] / _cby Peter L. Bonate. |
| 264 | 1 |
_aBoston, MA : _bSpringer US, _c2006. |
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| 300 |
_aXII, 387 p. _bonline resource. |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_acomputer _bc _2rdamedia |
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| 338 |
_arecurso en línea _bcr _2rdacarrier |
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| 347 |
_atext file _bPDF _2rda |
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| 505 | 0 | _aThe Art of Modeling -- Linear Models and Regression -- Nonlinear Models and Regression -- Variance Models, Weighting, and Transformations -- Case Studies in Linear and Nonlinear Modeling -- Linear Mixed Effects Models -- Nonlinear Mixed Effects Models: Theory -- Nonlinear Mixed Effects Models: Practical Issues -- Nonlinear Mixed Effects Models: Case Studies. | |
| 520 | _aThis book presents both the art and science behind pharmacokinetic-pharmacodynamic modeling. Using a building-block approach, the author starts from linear and nonlinear models at the individual level and proceeds to develop more complex linear and nonlinear mixed effects models at the population level, with particular emphasis on showing the interrelationships between the various model types. The theory behind the methods are illustrated using real data drawn from the literature and from the author's own experiences in drug development. Data are analyzed using a variety of software, including SAS, WinNonlin, SAAM II, and NONMEM. A key component of the book is to show how models are accepted and rejected, ultimately leading to a useful and informative model that can be utilized using computer simulation to answer "what-if" questions. | ||
| 650 | 0 | _aMEDICINE. | |
| 650 | 0 | _aTOXICOLOGY. | |
| 650 | 1 | 4 | _aBIOMEDICINE. |
| 650 | 2 | 4 | _aPHARMACOLOGY/TOXICOLOGY. |
| 710 | 2 | _aSpringerLink (Online service) | |
| 773 | 0 | _tSpringer eBooks | |
| 776 | 0 | 8 |
_iPrinted edition: _z9780387271972 |
| 856 | 4 | 0 |
_uhttp://dx.doi.org/10.1007/b138744 _zVer el texto completo en las instalaciones del CICY |
| 912 | _aZDB-2-SBL | ||
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_2ddc _cER |
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_c56644 _d56644 |
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