000			04254nam a22004455i 4500
001			978-0-387-27270-2
003			DE-He213
005			20250710083938.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9780387272702 _a99780387272702
024	7		_a10.1007/b138851 _2doi
082	0	4	_a571.4 _223
100	1		_aSimon, Matthew. _eauthor.
245	1	0	_aEmergent Computation _h[recurso electrónico] : _bEmphasizing Bioinformatics / _cby Matthew Simon.
264		1	_aNew York, NY : _bSpringer New York, _c2005.
300			_aXIV, 423 p. 274 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aBiological and Medical Physics Biomedical Engineering, _x1618-7210
505	0		_aEmergent Computation: Bioinformatics -- A Review of Chemistry -- A Review of Aspects of Automata Theory -- The Beginning Numbers -- Regular Languages: DNA and RNA -- Context-Free Languages: DNA and RNA -- Context-Sensitive Languages: DNA, RNA, Proteins -- Turing Machines and Sub-Turing Machines -- Splicing Systems, H Systems -- tRNA Structure -- Semigroups and Bioinformatics -- Automata Theory and Disciplines Other than Bioinformatics -- Automata Theory: Non-Bioinformatics Emergent Computation.
520			_aEmergent Computation is concerned with recent applications of Mathematical Linguistics or Automata Theory. This subject has a primary focus upon "Bioinformatics" (the Genome and arising interest in the Proteome), but the closing chapter also examines applications in Biology, Medicine, Anthropology, etc. The book is composed of an organized examination of DNA, RNA, and the assembly of amino acids into proteins. Rather than examine these areas from a purely mathematical viewpoint (that excludes much of the biochemical reality), the author uses scientific papers written mostly by biochemists based upon their laboratory observations. Thus while DNA may exist in its double stranded form, triple stranded forms are not excluded. Similarly, while bases exist in Watson-Crick complements, mismatched bases and abasic pairs are not excluded, nor are Hoogsteen bonds. Just as there are four bases naturally found in DNA, the existence of additional bases is not ignored, nor amino acids in addition to the usual complement of 20. Can there be more than "64" possible codons? RNA is examined from the point of view of Nussinov plots. All information is presented from the point of view of regular, context-free, and context sensitive languages, as well as Turing machines and Sequential Machines (and their corresponding semi-groups). Relationships to other subjects of mathematics such as Complex numbers, Quaternions, Algebraic-Topology, and Knot Theory are also mentioned. An examination is made of Splicing Systems as well as Dominoes. Shortcomings illustrating the dangers of mathematical abstractions that ignore biochemistry are pointed out. The papers examine the subjects of interest from the point of view of applying language theory to search for new results, but also as biological-automatons (implementations or machines) to do calculations. This book will be of value to those studying Bioinformatics, Biochemistry, Computer-Science, Mathematical Linguistics, and Biology, as well as Pharmacology (with the possible promise of medically active artificial DNA, RNA, and proteins). Laboratory results to demonstrate the usefulness of the topics discussed are demonstrated both in vitro and in vivo.
650		0	_aPHYSICS.
650		0	_aBIOCHEMICAL ENGINEERING.
650		0	_aBIOMEDICAL ENGINEERING.
650	1	4	_aPHYSICS.
650	2	4	_aBIOPHYSICS/BIOMEDICAL PHYSICS.
650	2	4	_aBIOMEDICAL ENGINEERING.
650	2	4	_aBIOCHEMICAL ENGINEERING.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387220468
830		0	_aBiological and Medical Physics Biomedical Engineering, _x1618-7210
856	4	0	_uhttp://dx.doi.org/10.1007/b138851 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-PHA
942			_2ddc _cER
999			_c56650 _d56650