000			03275nam a22004455i 4500
001			978-0-387-27530-7
003			DE-He213
005			20250710083938.0
007			cr nn 008mamaa
008			100301s2005 xxu| s |||| 0|eng d
020			_a9780387275307 _a99780387275307
024	7		_a10.1007/0-387-27530-4 _2doi
082	0	4	_a611.01816 _223
100	1		_aNaveh-Many, Tally. _eauthor.
245	1	0	_aMolecular Biology of the Parathyroid _h[recurso electrónico] / _cby Tally Naveh-Many.
264		1	_aBoston, MA : _bSpringer US, _c2005.
300			_aXIV, 199 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMolecular Biology Intelligence Unit
505	0		_aDevelopment of Parathyroid Glands -- Parathyroid Hormone, from Gene to Protein -- Toward an Understanding of Human Parathyroid Hormone Structure and Function -- The Calcium Sensing Receptor -- Regulation of Parathyroid Hormone mRNA Stability by Calcium and Phosphate -- In Silico Analysis of Regulatory Sequences in the Human Parathyroid Hormone Gene -- Regulation of Parathyroid Hormone Gene Expression by 1,25-Dihydroxyvitamin D -- Vitamin D Analogs for the Treatment of Secondary Hyperparathyroidism in Chronic Renal Failure -- Parathyroid Gland Hyperplasia in Renal Failure -- Molecular Mechanisms in Parathyroid Tumorigenesis -- Molecular Genetic Abnormalities in Sporadic Hyperparathyroidism -- Genetic Causes of Hypoparathyroidism -- Skeletal and Reproductive Abnormalities in Pth-Null Mice.
520			_aThe unraveling of the biology and disease mechanisms of the parathyroid has taken great strides in the recent few years. Parathyroid molecular biology is the first book to describe recent studies and discoveries in the field in detail. Key topics addressed include: The study of the molecular biology of the parathyroid hormone gene and its regulation by calcium, phosphate, and vitamin D The generation of mice with genetic deletions of the parathyroid, as well as mice which fail to develop the parathyroid gland The parathyroid's connection to the calcium receptor and its effects, such as regulation of PTH secretion, gene expression, and proliferation The genetic mutations leading to diseases of decreased or excessive activity of the parathyroid The mechanisms of actions associated with patients with chronic renal failure and the development of markedly excessive activity of the parathyroid that causes severe bone disease This book will be essential reading to everyone interested in the latest developments in this burgeoning field.
650		0	_aMEDICINE.
650		0	_aENDOCRINOLOGY.
650		0	_aNEPHROLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aMOLECULAR MEDICINE.
650	2	4	_aNEPHROLOGY.
650	2	4	_aENDOCRINOLOGY.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780306478475
830		0	_aMolecular Biology Intelligence Unit
856	4	0	_uhttp://dx.doi.org/10.1007/0-387-27530-4 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c56681 _d56681