000			03812nam a22004215i 4500
001			978-0-387-31416-7
003			DE-He213
005			20250710083948.0
007			cr nn 008mamaa
008			100301s2007 xxu| s |||| 0|eng d
020			_a9780387314167 _a99780387314167
024	7		_a10.1007/978-0-387-31416-7 _2doi
082	0	4	_a616.4 _223
100	1		_aCastracane, V. Daniel. _eeditor.
245	1	0	_aLeptin _h[recurso electrónico] / _cedited by V. Daniel Castracane, Michael C. Henson.
264		1	_aBoston, MA : _bSpringer US, _c2007.
300			_aXV, 371 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aEndocrine Updates, _x1566-0729 ; _v25
505	0		_aThe Obese (ob/ob) Mouse and the Discovery of Leptin -- Leptin Receptors -- Leptin and Obesity -- Leptin and Neuroendocrinology -- Leptin-Insulin Interrelationships -- Leptin and Other Endocrine Systems -- Leptin and Immune Function, Inflammation and Angiognenesis -- Leptin and Bone Central control of bone metabolism by leptin -- Roles and Regulation of Leptin in Reproduction -- Leptin and Cardiovascular Disease -- Leptin and Cancer -- Lipodystrophy: The experiment of nature to study leptin -- Pulsatile and Diurnal Leptin Rhythms -- Leptin in Farm Animals -- Genetic Disorders Involving Leptin and the Leptin Receptor -- Immunoassays for Leptin and Leptin Receptors -- Clinical Applications of Leptin.
520			_aThe discovery of leptin little more than a decade ago, as a hormone produced in white adipose tissue with an important role in satiety and energy expenditure, was a seminal event in our understanding of adiposity. This initial advance in the new endocrinology of obesity was soon followed by the realization that leptin was not only produced in adipose tissue, but in many different tissues of the body, and that receptors were similarly distributed. Additionally, the early recognition of infertility that was associated with leptin deficiency prompted research that identified roles for the polypeptide in virtually every area of reproductive biology. A general interest in leptin has rapidly produced inroads into unexpected areas of physiology that may eventually elucidate the varied relationships of adiposity to human health and disease. These developments have been paralleled by a rigorous investigation as a product of pharmaceutical interest. The broad range of physiology and the clinical situations in which leptin is now implicated is reviewed for the first time in the present volume. ***Series Editor's comments**** This volume integrates cutting edge basic and clinical information encompassing the expression of leptin and leptin receptors, pathophysiology and clinical role of leptin- a new neuroendocrine hormone with pleiotropic roles in appetite regulation, metabolic, inflammatory, neoplastic, cardiovascular and reproductive functions. This single volume encyclopedic coverage is indispensable to students, postdoctoral trainees, fellows, scientists and practitioners interested in neuroendocrine peptide control of multiple cellular functions. Shlomo Melmed, M.D. Series Editor Endocrine Updates
650		0	_aMEDICINE.
650		0	_aENDOCRINOLOGY.
650	1	4	_aMEDICINE & PUBLIC HEALTH.
650	2	4	_aENDOCRINOLOGY.
700	1		_aHenson, Michael C. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387314150
830		0	_aEndocrine Updates, _x1566-0729 ; _v25
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-31416-7 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SME
942			_2ddc _cER
999			_c57139 _d57139