000			03333nam a22005175i 4500
001			978-0-387-31910-0
003			DE-He213
005			20250710083949.0
007			cr nn 008mamaa
008			100301s2006 xxu| s |||| 0|eng d
020			_a9780387319100 _a99780387319100
024	7		_a10.1007/0-387-31910-7 _2doi
082	0	4	_a570.151 _223
100	1		_aMacheras, Panos. _eauthor.
245	1	0	_aModeling in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics _h[recurso electrónico] : _bHomogeneous and Heterogeneous Approaches / _cby Panos Macheras, Athanassios Iliadis.
264		1	_aNew York, NY : _bSpringer New York, _c2006.
300			_aXX, 442 p. 131 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aInterdisciplinary Applied Mathematics, _x0939-6047 ; _v30
505	0		_aBasic Concepts -- The Geometry of Nature -- Diffusion and Kinetics -- Nonlinear Dynamics -- Modeling in Biopharmaceutics -- Drug Release -- Drug Dissolution -- Oral Drug Absorption -- Modeling in Pharmacokinetics -- Empirical Models -- Deterministic Compartmental Models -- Stochastic Compartmental Models -- Modeling in Pharmacodynamics -- Classical Pharmacodynamics -- Nonclassical Pharmacodynamics.
520			_aThe state of the art in Biopharmaceutics, Pharmacokinetics, and Pharmacodynamics Modeling is presented in this book. It shows how advanced physical and mathematical methods can expand classical models in order to cover heterogeneous drug-biological processes and therapeutic effects in the body. The book is divided into four parts; the first deals with the fundamental principles of fractals, diffusion and nonlinear dynamics; the second with drug dissolution, release, and absorption; the third with empirical, compartmental, and stochastic pharmacokinetic models, and the fourth mainly with nonclassical aspects of pharmacodynamics. The classical models that have relevance and application to these sciences are also considered throughout. Many examples are used to illustrate the intrinsic complexity of drug administration related phenomena in the human, justifying the use of advanced modeling methods. This timely and useful book will appeal to graduate students and researchers in pharmacology, pharmaceutical sciences, bioengineering, and physiology.
650		0	_aMATHEMATICS.
650		0	_aTOXICOLOGY.
650		0	_aBIOCHEMISTRY.
650		0	_aBIOLOGY _xMATHEMATICS.
650		0	_aBIOMEDICAL ENGINEERING.
650	1	4	_aMATHEMATICS.
650	2	4	_aMATHEMATICAL BIOLOGY IN GENERAL.
650	2	4	_aPHARMACOLOGY/TOXICOLOGY.
650	2	4	_aBIOPHYSICS/BIOMEDICAL PHYSICS.
650	2	4	_aBIOMEDICAL ENGINEERING.
650	2	4	_aBIOCHEMISTRY, GENERAL.
650	2	4	_aAPPLICATIONS OF MATHEMATICS.
700	1		_aIliadis, Athanassios. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387281780
830		0	_aInterdisciplinary Applied Mathematics, _x0939-6047 ; _v30
856	4	0	_uhttp://dx.doi.org/10.1007/0-387-31910-7 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SMA
942			_2ddc _cER
999			_c57157 _d57157