000			03246nam a22004575i 4500
001			978-0-387-33777-7
003			DE-He213
005			20250710083952.0
007			cr nn 008mamaa
008			100301s2006 xxu| s |||| 0|eng d
020			_a9780387337777 _a99780387337777
024	7		_a10.1007/0-387-33777-6 _2doi
082	0	4	_a614.5999 _223
100	1		_aRuiz i Altaba, Ariel. _eauthor.
245	1	0	_aHedgehog-Gli Signaling in Human Disease _h[recurso electrónico] / _cby Ariel Ruiz i Altaba.
264		1	_aBoston, MA : _bSpringer US, _c2006.
300			_aXI, 228 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aMolecular Biology Intelligence Unit
505	0		_aHow the Hedgehog Outfoxed the Crab -- The Patched Receptor -- Making a Morphogenetic Gradient -- Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signaling -- Mode of PTCH1/Ptch1-Associated Tumor Formation -- Basal Cell Carcinomas, Hedgehog Signaling, and the Ptch1+/- Mouse -- GLI Genes and Their Targets in Epidermal Development and Disease -- Splitting Hairs -- Shh Expression in Pulmonary Injury and Disease -- Human Correlates of GLI3 Function -- From Oligodactyly to Polydactyly -- The Genetics of Indian Hedgehog -- Sonic Hedgehog Signaling in Craniofacial Development -- Important Role of Shh Controlling Gli3 Functions during the Dorsal-Ventral Patterning of the Telencephalon -- Regulation of Early Events in Cell Cycle Progression by Hedgehog Signaling in CNS Development and Tumorigenesis -- Modulating the Hedgehog Pathway in Diseases -- Hedgehog Signaling in Endodermally Derived Tumors.
520			_aHedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. The aim of the book is to disseminate information on this exciting field, to allow students, scientists and the public in general to gain access current information from research leaders and to provide a book that encompasses different aspects of research showing the fusion of basic research in model systems and medicine. This is a timely primer on how a system of cell communication, Hedgehog-GLI signaling, plays a critical role in human disease and thus provides the background for the development of novel and rational therapies.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aHUMAN GENETICS.
650		0	_aDEVELOPMENTAL BIOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aDEVELOPMENTAL BIOLOGY.
650	2	4	_aHUMAN GENETICS.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387257846
830		0	_aMolecular Biology Intelligence Unit
856	4	0	_uhttp://dx.doi.org/10.1007/0-387-33777-6 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c57306 _d57306