000			03972nam a22005175i 4500
001			978-0-387-36514-5
003			DE-He213
005			20250710083956.0
007			cr nn 008mamaa
008			100301s2007 xxu| s |||| 0|eng d
020			_a9780387365145 _a99780387365145
024	7		_a10.1007/978-0-387-36514-5 _2doi
082	0	4	_a612.8 _223
100	1		_aSu, Tsung-Ping. _eeditor.
245	1	0	_aSigma Receptors _h[recurso electrónico] : _bChemistry, Cell Biology and Clinical Implications / _cedited by Tsung-Ping Su, Rae R. Matsumoto, Wayne D. Bowen.
264		1	_aBoston, MA : _bSpringer US, _c2007.
300			_aXI, 413 p. 110 illus. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_a? Receptors: Historical Perspective and Background -- Medicinal Chemistry: New Chemical Classes and Subtype-Selective Ligands -- Irreversible ? Compounds -- Pharmacophore Models for ?1 Receptor Binding -- Cloning of ?1 Receptor and Structural Analysis of Its Gene and Promoter Region -- Site-Directed Mutagenesis -- ? Receptor Modulation of Ion Channels -- Subcellular Localization and Interacellular Dynamics of ?1 Receptors -- Intracellular Signaling and Synaptic Plasticity -- Modulation of Classical Neurotransmitter Systems by ? Receptors -- ?2 Receptors: Regulation of Cell Growth and Implications for Cancer Diagnosis and Therapeutics -- Cognitive Effects of ? Receptor Ligands -- ? Receptors and Scizophrenia -- Potential Role of ? Ligands and Neurosteroids in Major Depression -- ? Receptors and Drug Abuse -- ?1 Receptors and the Modulation of Opiate Analgesics -- ? Receptors in the Immune System: Implications for Potential Therapeutic Intervention - An Overview -- ? Receptors and Gastrointestinal Function.
520			_aSigma receptors are promising drug development targets for a host of neurological, psychiatric, oncological, immunological, cardiovascular, ophthalmological, and gastrointestinal disorders. They are structurally unique proteins that are distinct from classical G protein-coupled receptors, ionotropic receptors, or receptor tyrosine kinases. With two subtypes currently known, they modulate cell survival and excitability, and subserve many critical functions in the body. Endogenous ligands for these receptors are unknown, though current clues point to neurosteroids. This book provides a timely update on the medicinal chemistry, cell biology, and clinical implications of sigma receptors. It puts the information in a historical perspective to help new comers to the field successfully navigate the confusing early history surrounding these proteins, and provides a launching point for the development of exciting, new research. Sigma Receptors: Chemistry, Cell Biology and Clinical Implications will be a valuable tool for pharmacologists, medicinal chemists, cell biologists, molecular biologists, clinicians, and others interested in a concise, state-of-the-art overview of the sigma receptor field with a particular view towards novel therapeutic advances.
650		0	_aMEDICINE.
650		0	_aNEUROSCIENCES.
650		0	_aTOXICOLOGY.
650		0	_aPSYCHIATRY.
650		0	_aBIOCHEMISTRY.
650		0	_aCYTOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aNEUROSCIENCES.
650	2	4	_aPHARMACOLOGY/TOXICOLOGY.
650	2	4	_aBIOCHEMISTRY, GENERAL.
650	2	4	_aCELL BIOLOGY.
650	2	4	_aPSYCHIATRY.
650	2	4	_aMOLECULAR MEDICINE.
700	1		_aMatsumoto, Rae R. _eeditor.
700	1		_aBowen, Wayne D. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387365121
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-36514-5 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c57503 _d57503