000			02973nam a22004815i 4500
001			978-0-387-36673-9
003			DE-He213
005			20250710083956.0
007			cr nn 008mamaa
008			100301s2006 xxu| s |||| 0|eng d
020			_a9780387366739 _a99780387366739
024	7		_a10.1007/0-387-36673-3 _2doi
082	0	4	_a571.6 _223
100	1		_aGonzalez-Mariscal, Lorenza. _eauthor.
245	1	0	_aTight Junctions _h[recurso electrónico] / _cby Lorenza Gonzalez-Mariscal.
264		1	_aBoston, MA : _bSpringer US, _c2006.
300			_aXI, 224 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aEvolution of the Transporting Epithelium Phenotype -- Occludin, a Constituent of Tight Junctions -- Tight Junction Channels -- JAM Family Proteins -- Cingulin, a Cytoskeleton-Associated Protein of the Tight Junction -- ZO Proteins and Tight Junction Assembly -- TJ Proteins That Make Round Trips to the Nucleus -- Tight Junctions and the Regulation of Epithelial Cell Proliferation and Gene Expression -- Tight Junction Proteins and Cancer -- Regulation of Paracellular Transport across Tight Junctions by the Actin Cytoskeleton -- Regulation of Tight Junctions' Functional Integrity -- Tight Junctions during Development -- Tight Junctions and the Blood-Brain Barrier -- Tight Junctions in CNS Myelin -- Tight Junction Modulation and Its Relationship to Drug Delivery.
520			_aTight Junctions provides a state-of-the-art view on Tight Junctions (TJs). Starting with an analysis of the evolutionary development of a transporting epithelium in early metazoans, the book describes the current TJ structure and function information, including the present day evidence supporting the presence of ion channels within TJs. Particular emphasis is given to the lessons learned from cell culture models, mutant mice and heritable human diseases. To highlight the modern vision of TJs as signaling complexes, the book discusses the establishment of TJs during development, the shuttling of TJ proteins between the plasma membrane and the nucleus, and the role of TJ proteins in cell cycle progression and cancer.
650		0	_aLIFE SCIENCES.
650		0	_aONCOLOGY.
650		0	_aNEUROSCIENCES.
650		0	_aTOXICOLOGY.
650		0	_aCYTOLOGY.
650		0	_aNEUROBIOLOGY.
650	1	4	_aLIFE SCIENCES.
650	2	4	_aCELL BIOLOGY.
650	2	4	_aNEUROSCIENCES.
650	2	4	_aNEUROBIOLOGY.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aPHARMACOLOGY/TOXICOLOGY.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387332017
856	4	0	_uhttp://dx.doi.org/10.1007/0-387-36673-3 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c57514 _d57514