000			02825nam a22004215i 4500
001			978-0-387-47257-7
003			DE-He213
005			20250710084001.0
007			cr nn 008mamaa
008			100609s2006 xxu| s |||| 0|eng d
020			_a9780387472577 _a99780387472577
024	7		_a10.1007/978-0-387-47257-7 _2doi
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
100	1		_aSilverman, Scott K. _eauthor.
245	1	0	_aNucleic Acid Switches and Sensors _h[recurso electrónico] / _cby Scott K. Silverman.
264		1	_aBoston, MA : _bSpringer US, _c2006.
300			_aIX, 125 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aArtificial Nucleic Acid Switches and Sensors -- Allosteric Ribozymes as Molecular Switches and Sensors -- Ribozymes and Deoxyribozymes Switched by Oligonucleotides -- Ribozymes Switched by Proteins -- Fluorescence-Signaling Nucleic Acid-Based Sensors -- Natural Nucleic Acid Switches and Sensors -- Protein-Induced RNA Switches in Nature -- Riboswitches as Genetic Control Elements -- Switchable RNA Motifs as Drug Targets.
520			_aIn this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.
650		0	_aMEDICINE.
650		0	_aHUMAN GENETICS.
650		0	_aMICROBIOLOGY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aHUMAN GENETICS.
650	2	4	_aMEDICAL MICROBIOLOGY.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387374918
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-47257-7 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c57726 _d57726