000			04511nam a22005535i 4500
001			978-0-387-49686-3
003			DE-He213
005			20250710084004.0
007			cr nn 008mamaa
008			100301s2007 xxu| s |||| 0|eng d
020			_a9780387496863 _a99780387496863
024	7		_a10.1007/978-0-387-49686-3 _2doi
082	0	4	_a611.01816 _223
082	0	4	_a599.935 _223
100	1		_aSiegmund, David. _eauthor.
245	1	4	_aThe Statistics of Gene Mapping _h[recurso electrónico] / _cby David Siegmund, Benjamin Yakir.
264		1	_aNew York, NY : _bSpringer New York, _c2007.
300			_aXIX, 331 p. _bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
490	1		_aStatistics for Biology and Health, _x1431-8776
505	0		_aBackground and Preparations -- Background in Statistics -- to Experimental Genetics -- Fundamentals of Genetics: Inbreeding, Recombination, Random Mating, and Identity by Descent -- Experimental Genetics -- Testing for Linkage with a Single Marker -- Whole Genome Scans: The Significance Level -- Statistical Power and Confidence Regions -- Missing Data and Interval Mapping -- Advanced Topics -- Human Genetics -- Mapping Qualitative Traits in Humans Using Affected Sib Pairs -- Admixture Mapping -- Mapping Complex and Quantitative Traits with Data from Human Pedigrees -- Association Studies -- Inferring Haplotypes from Genotypes and Testing Association.
520			_aGene mapping is used in experimental genetics to improve the hardiness or productivity of animals or plants of agricultural value, to explore basic mechanisms of inheritance, or to study animal models of human inheritance. In human populations it is used as a first step to identify genes associated with human health and disease. This book presents a unified discussion of the statistical concepts applied in gene mapping, first in the experimental context of crosses of inbred lines and then in outbred populations, primarily humans. The development involves elementary principles of probability and statistics, which are implemented by computational tools based on the R programming language to simulate genetic experiments and evaluate statistical analyses. The viewpoint reflects the modern approach of using anonymous DNA markers distributed throughout the genome to identify regions likely to contain genes of interest. The reader is assumed to have some familiarity with probability/statistics and with elementary genetics. Important topics are reviewed in the first three chapters. The R programming language is developed in the text. Each chapter contains exercises, both theoretical and computational, some routine and others that are more challenging. The book is suitable for upper level undergraduate students or graduate students of genetics or statistics. David Siegmund is the John D. and Sigrid Banks Professor in the Department of Statistics,Stanford University. He has been a visitor at The Hebrew University, the University of Zurich, the University of Heidelberg, the National University of Singapore, and the Free University of Amsterdam. He is a member of the National Academy of Sciences (USA) and the American Academy of Arts and Sciences. Benjamin Yakir is Associate Professor of Statistics at The Hebrew University of Jerusalem and has been a visiting professor at Stanford University, the University of Pennsylvania, and the National University of Singapore.
650		0	_aMEDICINE.
650		0	_aHUMAN GENETICS.
650		0	_aCOMPUTER SIMULATION.
650		0	_aBIOINFORMATICS.
650		0	_aANIMAL GENETICS.
650		0	_aGENETICS _xMATHEMATICS.
650		0	_aSTATISTICS.
650	1	4	_aBIOMEDICINE.
650	2	4	_aHUMAN GENETICS.
650	2	4	_aBIOINFORMATICS.
650	2	4	_aSTATISTICS FOR LIFE SCIENCES, MEDICINE, HEALTH SCIENCES.
650	2	4	_aSIMULATION AND MODELING.
650	2	4	_aANIMAL GENETICS AND GENOMICS.
650	2	4	_aGENETICS AND POPULATION DYNAMICS.
700	1		_aYakir, Benjamin. _eauthor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387496849
830		0	_aStatistics for Biology and Health, _x1431-8776
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-49686-3 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c57871 _d57871