000			02599nam a22004935i 4500
001			978-0-387-69147-3
003			DE-He213
005			20250710084009.0
007			cr nn 008mamaa
008			100301s2009 xxu| s |||| 0|eng d
020			_a9780387691473 _a99780387691473
024	7		_a10.1007/978-0-387-69147-3 _2doi
082	0	4	_a614.5999 _223
100	1		_aRubin, Eric. _eeditor.
245	1	0	_aModulation of Protein Stability in Cancer Therapy _h[recurso electrónico] / _cedited by Eric Rubin, Kathleen Sakamoto.
264		1	_aNew York, NY : _bSpringer US, _c2009.
300			_bonline resource.
336			_atext _btxt _2rdacontent
337			_acomputer _bc _2rdamedia
338			_arecurso en línea _bcr _2rdacarrier
347			_atext file _bPDF _2rda
505	0		_aUbiquitin Ligases and Cancer -- The 26S Proteasome as a Therapeutic Target in Cancer: Beyond Protease Inhibitors? -- Targeting HAUSP: Killing Two Birds with One Stone -- Modulation of Protein Stability: Targeting the VHL Pathway -- Interrelationship of the Fanconi Anemia/BRCA Pathway -- Targeting the Sumoylation Pathway -- Proteasome Inhibitors -- Targeting Deubiquitinating Enzymes -- Proteolysis Targeting Chimeric Molecules.
520			_aThis book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed. Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described.
650		0	_aMEDICINE.
650		0	_aONCOLOGY.
650		0	_aHUMAN GENETICS.
650		0	_aIMMUNOLOGY.
650		0	_aMICROBIOLOGY.
650		0	_aBIOCHEMISTRY.
650	1	4	_aBIOMEDICINE.
650	2	4	_aCANCER RESEARCH.
650	2	4	_aMEDICAL MICROBIOLOGY.
650	2	4	_aHUMAN GENETICS.
650	2	4	_aIMMUNOLOGY.
650	2	4	_aBIOCHEMISTRY, GENERAL.
700	1		_aSakamoto, Kathleen. _eeditor.
710	2		_aSpringerLink (Online service)
773	0		_tSpringer eBooks
776	0	8	_iPrinted edition: _z9780387691435
856	4	0	_uhttp://dx.doi.org/10.1007/978-0-387-69147-3 _zVer el texto completo en las instalaciones del CICY
912			_aZDB-2-SBL
942			_2ddc _cER
999			_c58095 _d58095